UniProt Accession

 D6REF7_MOUSE; D6REF7 

Genbank Protein ID

 AC123530; AC153515 

Genbank Nucleotide ID

  

Protein Name

 Sphingosine-1-phosphate lyase 1 

Protein Synonyms/Alias

  

Gene Name

 Sgpl1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
353	SISADTHKYGYAPKG	acetylation	[1, 2, 3]
353	SISADTHKYGYAPKG	ubiquitination	[4]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Lyase; Pyridoxal phosphate; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 487 AA 

Protein Sequence

Gene Ontology

 GO:0016831; F:carboxy-lyase activity; IEA:InterPro.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0008209; P:androgen metabolic process; IMP:MGI.
 GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
 GO:0008210; P:estrogen metabolic process; IMP:MGI.
 GO:0060325; P:face morphogenesis; IMP:MGI.
 GO:0010761; P:fibroblast migration; IMP:MGI.
 GO:0030097; P:hemopoiesis; IMP:MGI.
 GO:0001822; P:kidney development; IMP:MGI.
 GO:0033327; P:Leydig cell differentiation; IMP:MGI.
 GO:0001553; P:luteinization; IMP:MGI.
 GO:0006807; P:nitrogen compound metabolic process; IMP:MGI.
 GO:0060021; P:palate development; IMP:MGI.
 GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IMP:MGI.
 GO:0009791; P:post-embryonic development; IMP:MGI.
 GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.
 GO:0048705; P:skeletal system morphogenesis; IMP:MGI.
 GO:0007283; P:spermatogenesis; IMP:MGI.
 GO:0001570; P:vasculogenesis; IMP:MGI. 

Interpro

 IPR002129; PyrdxlP-dep_de-COase.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1. 

Pfam

 PF00282; Pyridoxal_deC 

SMART

  

PROSITE

  

PRINTS