CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013085
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 
Protein Synonyms/Alias
  
Gene Name
 Arfgef3 
Gene Synonyms/Alias
 Big3; D10Bwg1379e; Kiaa1244 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
48PPHLLREKCLLPLQLubiquitination[1]
60LQLALESKNVKLAQHubiquitination[1]
1399RCSQLLAKIYKMPLKubiquitination[1]
1791GLKCLLKKVSGIGGAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
 DOMAIN 579 792 SEC7.
 MOD_RES 1646 1646 Phosphoserine.
 MOD_RES 1881 1881 Phosphoserine.  
Keyword
 Complete proteome; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2170 AA 
Protein Sequence
MEEILRKLQR DASGSKYKAI KESCTWALET LGGLDTVVKI PPHLLREKCL LPLQLALESK 60
NVKLAQHALA GMQKLLSEER FVSMETDSDE KQLLNQILNA VKVTPSLNED LQVEVMKVLL 120
CITYTPTFDM NGSAVLKIAE VCIETYTCSC HQRSINTAVR ATLSQMLGDL TLQLRQRQEN 180
TIIENPDAPQ EFRSQGLTVE ALCDDVISVL AVLCEKLQAS INDSQQLQLL YLECILSVLS 240
SSSSSMHLHR GFTDLIWKSL CPALVVILGN PIHDKTITSA HSTSTSTSME SDSASLGVSD 300
HGRGSGCSCT APTLSGPVAR TIYYLAAELV RLVGSVDSMK PVLQSLYHRV LLYPPPQHRV 360
EAIKIMKEIL GSPQRLYDLA GPSSIESEPR KRSISKRKSH LDLLKLIMDG MTEACIKGGI 420
EACYAAVSCV CTLLGALDEL SQGKGLNDTQ VQQLLLRLEE LRDGAESSRD SMEINEADFR 480
WQRRVLSSEH TPWESGNERS PDISISVTTD TGQTTLEGEL GQTTPEDHKN GLKSPAIQEG 540
KGTMGKVSEP EAIDQPDVVQ RSHTVPYPDI TNFLSVDCRT RSYGSRYSES NFSVDDQDLS 600
RTEFDSCDQY SMAAEKDSGR SDVSDIGSDN CSLADEEQTP RDYIGHRSLR TAALSLKLLK 660
NQEADQHSAR LFIQSLEGLL PRLLALSSVE EVDSALQNFA STFCSGMMHS PGFDGGSSLS 720
FQMLMNADSL YTAAHCALLL NLKLSHGDYY RKRPTVAPGM MKEFMKQVQT SGVLMVFSQA 780
WLEELYHQVL DRNMLGEAGY WGSPEDNSLP LITMLTDIDG LESSAIGGQL MASASVESPF 840
TQSRRLDDST VAGVAFARYI LVGCWKNLID TLSTPLTGRM AGSSKGLAFI LGAEGIKEQN 900
QKERDAICMS LDGLRKAARL SCALGVAANC ASALAQMAAA SCVQEEKEER QSQEPSDALA 960
QVKLKVEQKL EQMGKVQGVW LHTAHVLCMD AILSVGLEMG SHNPDCWPHV FRVCEYVGTL 1020
EHTHFSDGIS QPPLTIHQPQ KTSGSSGLLG EIEFKSSSQE QSLEQGPSLN TAPVVQPHSI 1080
QELVRECSRG RTSDFRGGSL SGNSAAKVVL SLSTQADRLF DDATDKLNLT ALGGFLYQLK 1140
KASQSQLFHS VTDTVDYSLT MPGEVKSTQD QKSALHLFRL GDAMLRIVRS KARPLLHVMR 1200
CWSLVAPHLV EAACHKERHV SQKAVSFIHD ILTEVLTDWS EPPHFHFNEA LFRPFERIMQ 1260
LELCDEDVQD QVVTSIGELV EVCSAQIQSG WRPLFSALET VRSGNKSEVK EYLVGDYSMG 1320
KGQAPVFDVF EAFLNTDNIQ VFANAATSYI MCLMKFVKGL GEVDCKEIGD CVPGAGATST 1380
DLCLPALDYL RRCSQLLAKI YKMPLKPIFL SGRLASLPRR LQEQSASSED GIESVLSDFD 1440
DDTGLIEVWI ILLEQLTAAV SNCPRQHQPP TLDLLFELLR DVTKTPGPGF GIYAVVHLLL 1500
PVMSLWLLRS HKDHSYWDVA SANFKHAIGL SCELVVEHIQ SFLHSDIRYE SMINTMLKDL 1560
FELLVVCVAK PTETISRVGC SCIRYVLVTA GPVFTEEMWR LACCALQDAF SATLKPVKDL 1620
LGCFHGGTEG FSGEGCQVRV AAPSSSPSAE AEYWRIRAMA QQVFMLDTQC SPKTPNNFDH 1680
AQSCQLIIEL PHDEKPNGHA KKSVSFREIV VSLLSHQVLL QNLYDILLEE FVKGPSPGEE 1740
KTVQVPDTKL AGFLRYISMQ NLAVIFDLLL DSYRTAREFD TSPGLKCLLK KVSGIGGAAN 1800
LYRQSAMSFN IYFHALVCAV LTNQETITAE QVKKVLFEEE ERSSDSSQQC SSEDEDIFEE 1860
TAQVSPPRGK EKRQWRARLP SLSVQPVSNA DWVWLVKRLH KLCMELCNHY IQMHLDLESS 1920
LEEPLTFKSD PFFILPSFQS ESSTPSTGGF SGKNTPSEDD RREHLSEPQS LRVGSGDMLM 1980
LPPSPKTEKK DPGRKKEWWE SAGNKICTMA ADKTISKLMT EYKKRRQPHN LPPFPKEVKV 2040
DKKGEPLGPR GPDSPLLQRP QHLIDQGQMR HSFSAGPELL RQEKRPRSGS TGSSLSVSVR 2100
DAEAQIQAWT NMVLTVLNQI QILPDQTFTA LQPAVFPCIS QLTCHVTDIR VRQAVREWLG 2160
RVGRVYDIIT 2170 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005802; C:trans-Golgi network; IBA:RefGenome.
 GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IBA:RefGenome.
 GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB.
 GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IBA:RefGenome. 
Interpro
 IPR015403; DUF1981_SEC7_assoc.
 IPR000904; Sec7. 
Pfam
 PF09324; DUF1981 
SMART
 SM00222; Sec7 
PROSITE
 PS50190; SEC7 
PRINTS