Tag | Content |
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CPLM ID | CPLM-013085 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 |
Protein Synonyms/Alias | |
Gene Name | Arfgef3 |
Gene Synonyms/Alias | Big3; D10Bwg1379e; Kiaa1244 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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48 | PPHLLREKCLLPLQL | ubiquitination | [1] | 60 | LQLALESKNVKLAQH | ubiquitination | [1] | 1399 | RCSQLLAKIYKMPLK | ubiquitination | [1] | 1791 | GLKCLLKKVSGIGGA | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | |
Sequence Annotation | DOMAIN 579 792 SEC7. MOD_RES 1646 1646 Phosphoserine. MOD_RES 1881 1881 Phosphoserine. |
Keyword | Complete proteome; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2170 AA |
Protein Sequence | MEEILRKLQR DASGSKYKAI KESCTWALET LGGLDTVVKI PPHLLREKCL LPLQLALESK 60 NVKLAQHALA GMQKLLSEER FVSMETDSDE KQLLNQILNA VKVTPSLNED LQVEVMKVLL 120 CITYTPTFDM NGSAVLKIAE VCIETYTCSC HQRSINTAVR ATLSQMLGDL TLQLRQRQEN 180 TIIENPDAPQ EFRSQGLTVE ALCDDVISVL AVLCEKLQAS INDSQQLQLL YLECILSVLS 240 SSSSSMHLHR GFTDLIWKSL CPALVVILGN PIHDKTITSA HSTSTSTSME SDSASLGVSD 300 HGRGSGCSCT APTLSGPVAR TIYYLAAELV RLVGSVDSMK PVLQSLYHRV LLYPPPQHRV 360 EAIKIMKEIL GSPQRLYDLA GPSSIESEPR KRSISKRKSH LDLLKLIMDG MTEACIKGGI 420 EACYAAVSCV CTLLGALDEL SQGKGLNDTQ VQQLLLRLEE LRDGAESSRD SMEINEADFR 480 WQRRVLSSEH TPWESGNERS PDISISVTTD TGQTTLEGEL GQTTPEDHKN GLKSPAIQEG 540 KGTMGKVSEP EAIDQPDVVQ RSHTVPYPDI TNFLSVDCRT RSYGSRYSES NFSVDDQDLS 600 RTEFDSCDQY SMAAEKDSGR SDVSDIGSDN CSLADEEQTP RDYIGHRSLR TAALSLKLLK 660 NQEADQHSAR LFIQSLEGLL PRLLALSSVE EVDSALQNFA STFCSGMMHS PGFDGGSSLS 720 FQMLMNADSL YTAAHCALLL NLKLSHGDYY RKRPTVAPGM MKEFMKQVQT SGVLMVFSQA 780 WLEELYHQVL DRNMLGEAGY WGSPEDNSLP LITMLTDIDG LESSAIGGQL MASASVESPF 840 TQSRRLDDST VAGVAFARYI LVGCWKNLID TLSTPLTGRM AGSSKGLAFI LGAEGIKEQN 900 QKERDAICMS LDGLRKAARL SCALGVAANC ASALAQMAAA SCVQEEKEER QSQEPSDALA 960 QVKLKVEQKL EQMGKVQGVW LHTAHVLCMD AILSVGLEMG SHNPDCWPHV FRVCEYVGTL 1020 EHTHFSDGIS QPPLTIHQPQ KTSGSSGLLG EIEFKSSSQE QSLEQGPSLN TAPVVQPHSI 1080 QELVRECSRG RTSDFRGGSL SGNSAAKVVL SLSTQADRLF DDATDKLNLT ALGGFLYQLK 1140 KASQSQLFHS VTDTVDYSLT MPGEVKSTQD QKSALHLFRL GDAMLRIVRS KARPLLHVMR 1200 CWSLVAPHLV EAACHKERHV SQKAVSFIHD ILTEVLTDWS EPPHFHFNEA LFRPFERIMQ 1260 LELCDEDVQD QVVTSIGELV EVCSAQIQSG WRPLFSALET VRSGNKSEVK EYLVGDYSMG 1320 KGQAPVFDVF EAFLNTDNIQ VFANAATSYI MCLMKFVKGL GEVDCKEIGD CVPGAGATST 1380 DLCLPALDYL RRCSQLLAKI YKMPLKPIFL SGRLASLPRR LQEQSASSED GIESVLSDFD 1440 DDTGLIEVWI ILLEQLTAAV SNCPRQHQPP TLDLLFELLR DVTKTPGPGF GIYAVVHLLL 1500 PVMSLWLLRS HKDHSYWDVA SANFKHAIGL SCELVVEHIQ SFLHSDIRYE SMINTMLKDL 1560 FELLVVCVAK PTETISRVGC SCIRYVLVTA GPVFTEEMWR LACCALQDAF SATLKPVKDL 1620 LGCFHGGTEG FSGEGCQVRV AAPSSSPSAE AEYWRIRAMA QQVFMLDTQC SPKTPNNFDH 1680 AQSCQLIIEL PHDEKPNGHA KKSVSFREIV VSLLSHQVLL QNLYDILLEE FVKGPSPGEE 1740 KTVQVPDTKL AGFLRYISMQ NLAVIFDLLL DSYRTAREFD TSPGLKCLLK KVSGIGGAAN 1800 LYRQSAMSFN IYFHALVCAV LTNQETITAE QVKKVLFEEE ERSSDSSQQC SSEDEDIFEE 1860 TAQVSPPRGK EKRQWRARLP SLSVQPVSNA DWVWLVKRLH KLCMELCNHY IQMHLDLESS 1920 LEEPLTFKSD PFFILPSFQS ESSTPSTGGF SGKNTPSEDD RREHLSEPQS LRVGSGDMLM 1980 LPPSPKTEKK DPGRKKEWWE SAGNKICTMA ADKTISKLMT EYKKRRQPHN LPPFPKEVKV 2040 DKKGEPLGPR GPDSPLLQRP QHLIDQGQMR HSFSAGPELL RQEKRPRSGS TGSSLSVSVR 2100 DAEAQIQAWT NMVLTVLNQI QILPDQTFTA LQPAVFPCIS QLTCHVTDIR VRQAVREWLG 2160 RVGRVYDIIT 2170 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005802; C:trans-Golgi network; IBA:RefGenome. GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IBA:RefGenome. GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB. GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro. GO:0016192; P:vesicle-mediated transport; IBA:RefGenome. |
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Pfam | |
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PROSITE | |
PRINTS | |