UniProt Accession

 FABP5_MOUSE; Q05816 

Genbank Protein ID

 X70100; AJ223066; AF061015; AF061014; AK008782; AK011551; BC002008 

Genbank Nucleotide ID

 CAA49703.1; CAA11069.1; AAC82368.1; AAC82368.1; BAB25890.1; BAB27692.1; AAH02008.1 

Protein Name

 Fatty acid-binding protein, epidermal 

Protein Synonyms/Alias

 Epidermal-type fatty acid-binding protein; E-FABP; Fatty acid-binding protein 5; Keratinocyte lipid-binding protein; Psoriasis-associated fatty acid-binding protein homolog; PA-FABP 

Gene Name

 Fabp5 

Gene Synonyms/Alias

 Fabpe; Klbp; Mal1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
24	HGFEEYMKELGVGLA	ubiquitination	[1]
34	GVGLALRKMAAMAKP	ubiquitination	[1]
40	RKMAAMAKPDCIITC	acetylation	[2]
55	DGNNITVKTESTVKT	acetylation	[2]
61	VKTESTVKTTVFSCN	acetylation	[2]
61	VKTESTVKTTVFSCN	ubiquitination	[1]
72	FSCNLGEKFDETTAD	acetylation	[2]
82	ETTADGRKTETVCTF	acetylation	[2, 3]
82	ETTADGRKTETVCTF	succinylation	[3]
103	QHQQWDGKESTITRK	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 High specificity for fatty acids. Highest affinity for C18 chain length (By similarity). 

Sequence Annotation

 REGION 129 131 Fatty acid binding (By similarity).
 BINDING 109 109 Fatty acid (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 131 131 Phosphotyrosine (By similarity).
 DISULFID 120 127 By similarity.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Lipid-binding; Phosphoprotein; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 135 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0006006; P:glucose metabolic process; IMP:MGI.
 GO:0015758; P:glucose transport; IMP:MGI.
 GO:0006656; P:phosphatidylcholine biosynthetic process; IGI:MGI. 

Interpro

 IPR012674; Calycin.
 IPR011038; Calycin-like.
 IPR000463; Fatty_acid-bd.
 IPR000566; Lipocln_cytosolic_FA-bd_dom. 

Pfam

 PF00061; Lipocalin 

SMART

  

PROSITE

 PS00214; FABP 

PRINTS

 PR00178; FATTYACIDBP.