UniProt Accession

 SPF30_MOUSE; Q8BGT7; Q4QQL0 

Genbank Protein ID

 DQ479929; AK078834; AK090047; BC058779; BC098223 

Genbank Nucleotide ID

 ABF48508.1; BAC37414.1; BAC41064.1; AAH58779.1; AAH98223.1 

Protein Name

 Survival of motor neuron-related-splicing factor 30 

Protein Synonyms/Alias

 30 kDa splicing factor SMNrp; SMN-related protein; Survival motor neuron domain-containing protein 1 

Gene Name

 Smndc1 

Gene Synonyms/Alias

 Smnr; Spf30 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
219	GTCGIADKPMTQYQD	acetylation	[1, 2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Necessary for spliceosome assembly. Overexpression causes apoptosis (By similarity). 

Sequence Annotation

 DOMAIN 72 132 Tudor.
 MOTIF 142 160 Nuclear localization signal (Potential).
 MOD_RES 201 201 Phosphoserine (By similarity).
 MOD_RES 219 219 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Apoptosis; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 238 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR010304; Survival_motor_neuron.
 IPR002999; Tudor. 

Pfam

 PF06003; SMN 

SMART

 SM00333; TUDOR 

PROSITE

 PS50304; TUDOR 

PRINTS