Tag | Content |
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CPLM ID | CPLM-011536 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vacuolar protein sorting-associated protein 13 |
Protein Synonyms/Alias | Suppression of the onset of impotence protein 1; Vacuolar protein-targeting protein 2 |
Gene Name | VPS13 |
Gene Synonyms/Alias | SOI1; VPT2; YLL040C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
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133 | LSTQSENKTSSSSSE | ubiquitination | [1] | 452 | IEPQTSNKSATKNNG | ubiquitination | [1] | 882 | LQLKNTLKALENMQP | ubiquitination | [1] | 1357 | NSGESGGKGEIKSPS | ubiquitination | [1] | 1894 | DKTTEDNKNEVVLLK | ubiquitination | [1] |
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Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Required for sorting signal-dependent recycling of membrane proteins between an endocytic compartment and the TGN. |
Sequence Annotation | MOD_RES 1364 1364 Phosphoserine. MOD_RES 1382 1382 Phosphoserine. MOD_RES 1715 1715 Phosphoserine. MOD_RES 1729 1729 Phosphoserine. MOD_RES 1731 1731 Phosphoserine. |
Keyword | Complete proteome; Golgi apparatus; Phosphoprotein; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 3144 AA |
Protein Sequence | MLESLAANLL NRLLGSYVEN FDPNQLNVGI WSGDVKLKNL KLRKDCLDSL NLPIDVKSGI 60 LGDLVLTVPW SSLKNKPVKI IIEDCYLLCS PRSEDHENDE EMIKRAFRLK MRKVSEWELT 120 NQARILSTQS ENKTSSSSSE KNNAGFMQSL TTKIIDNLQV TIKNIHLRYE DMDGIFTTGP 180 SSVGLTLNEL SAVSTDSNWA PSFIDITQNI THKLLTLNSL CLYWNTDSPP LISDDDQDRS 240 LENFVRGFKD MIASKNSTAP KHQYILKPVS GLGKLSINKL GSTEEQPHID LQMFYDEFGL 300 ELDDTEYNDI LHVLSSIQLR QITKKFKKAR PSFAVSENPT EWFKYIAACV INEIHEKNKM 360 WTWESMKEKC EQRRLYTKLW VEKLKLKNLE APLRDPIQEA QLSELHKDLT YDEIILFRSV 420 AKRQYAQYKL GMTEDSPTPT ASSNIEPQTS NKSATKNNGS WLSSWWNGKP TEEVDEDLIM 480 TEEQRQELYD AIEFDENEDK GPVLQVPRER VELRVTSLLK KGSFTIRKKK QNLNLGSIIF 540 ENCKVDFAQR PDSFLSSFQL NKFSLEDGSP NALYKHIISV RNSSKDQSSI DNHATGEEEE 600 EDEPLLRASF ELNPLDGLAD SNLNIKLLGM TVFYHVHFIT EVHKFFKASN QHMETIGNIV 660 NAAEATVEGW TTQTRMGIES LLEDHKTVNV SLDLQAPLII LPLDPHDWDT PCAIIDAGHM 720 SILSDLVPKE KIKEIKELSP EEYDKIDGNE INRLMFDRFQ ILSQDTQIFV GPDIQSTIGK 780 INTASSTNDF RILDKMKLEL TVDLSILPKA YKLPTIRVFG HLPRLSLSIN DIQYKTIMNL 840 IANSIPSMID DEENNGDYVN YSSGSEKEMK KQIQLQLKNT LKALENMQPL QIEQKFLELH 900 FDIDQAKIAF FQCIKNDSRN SEKLVDILCQ RLNFNFDKRA KEMNLDLRVH SLDVEDYIEL 960 TDNKEFKNLI SSGVEKVTRS QKDLFTLKYK RVQRIVPHND TLIELFDQDI VMHMSELQLV 1020 LTPRSVLTLM NYAMLTFTDP NAPEMPADVL RHNKEDRDDA PQKINMKIKM EAVNVIFNDD 1080 SIKLATLVLS AGEFTMVLLP ERYNINLKLG GLELTDETNE SFSRDSVFRK IIQMKGQELV 1140 ELSYESFDPA TNTKDYDSFL KYSTGSMHVN FIESAVNRMV NFFAKFQKSK VSFDRARLAA 1200 YNQAPSIDAV NNMKMDIVIK APIIQFPKLV GTQENNYDTM RFYLGEFFIE NKFSVIDESH 1260 KINHIKLGVR EGQLSSNLNF DGSSQQLYLV ENIGLLFNID RDPLPQDDTP ELKVTSNFES 1320 FALDLTENQL TYLLEISNKV SSAFNITDEN SGESGGKGEI KSPSPDPASL SSESERTATP 1380 QSLQGSNKSN IKNPEQKYLD FSFKAPKIAL TLYNKTKGVT SLNDCGLTRI MFQDIGCSLG 1440 LKNDGTVDGQ AHVAAFRIED VRNIKDNKHT ELIPKSKNKE YQFVANISRK NLEVGRLLNI 1500 SMTMDSPKMI LAMDYLVSLK EFFDAIMSKS HENNLYYPEN TNQKPENKAI VESVQEGGDV 1560 TKIQYSVNII ETALILLADP CDMNSEAISF KIGQFLVTDQ NIMTVAANNV GIFLFKMNSS 1620 EEKLRLLDDF SSSLTIDKRN STPQTLMTNI QLSVQPLLMR ISLRDIRLAM LIFKRVTTLL 1680 NKMTEKEDNG EEEESTDKIQ FSHEFERKLA VLDPSILGER SRASQSSDSE SIEVPTAILK 1740 NETFNADLGG LRFILIGDVH EMPILDMNVN EITASAKDWS TDFEALASLE TYVNIFNYSR 1800 SSWEPLLEMI PITFHLSKGH SEMDPAFSFD ILTQRIAEIT LSARSIAMLS HIPASLTEEL 1860 PLASRVSQKP YQLVNDTELD FDVWIQDKTT EDNKNEVVLL KANTSLPWEF EDWRSIREKL 1920 DIDKSKNILG VCVSGQNYKT IMNIDATTEG ENLHVLSPPR NNVHNRIVCE ARCDENNVKI 1980 ITFRSTLVIE NTTSTEIELL VDSKDPNKPS LKYAIKPHQS KSVPVEYAYD SDIRIRPASE 2040 DIYDWSQQTL SWKSLLSNQM SIFCSSKEDS NQRFHFEIGA KYDEREPLAK IFPHMKIVVS 2100 ASMTIENLLP ADINFSIFDK REEKRTDFLK TGESMEVHHI SLDSFLLMSV QPLQDEASAS 2160 KPSIVNTPHK SPLNPEDSLS LTLSGGQNLL LKLDYKNIDG TRSKVIRIYS PYIIMNSTDR 2220 ELYIQSSLLN IAQSKILLEN EKRYTIPKMF SFDKEDDKSN RARIRFKESE WSSKLSFDAI 2280 GQSFDASVRI KNKEQESNLG INISEGKGKY LLSKVIEIAP RYIISNTLDI PIEVCETGSM 2340 DVQQIESNIT KPLYRMRNIV DKQLVLKFLG GDSNWSQPFF IKNVGVTYLK VLKNSRHKLL 2400 KIEILLDKAT IFIRIKDGGD RWPFSIRNFS DHDFIFYQRD PRKVSDPYKD DQSNESSSRS 2460 FKPIFYRIPS KSIMPYAWDF PTAKEKYLVL ESGTRTREVR LAEIGELPPL RLDKRSKDKP 2520 APIVGLHVVA DDDMQALVIV NYKANVGLYK LKTASATTTS SVSVNSSVTD GFVQKDEDEK 2580 VNTQIVVSFK GVGISLINGR LQELLYINMR GIELRYNESK AYQTFSWKMK WMQIDNQLFS 2640 GNYSNILYPT EIPYTEKEIE NHPVISGSIS KVNDSLQAVP YFKHVTLLIQ EFSIQLDEDM 2700 LYAMMDFIKF PGSPWIMDSR DYKYDEEIQL PDVSELKTAG DIYFEIFHIQ PTVLHLSFIR 2760 SDEISPGLAE ETEESFSSSL YYVHMFAMTL GNINEAPVKV NSLFMDNVRV PLPILMDHIE 2820 RHYTTQFVYQ IHKILGSADC FGNPVGLFNT ISSGVWDLFY EPYQGYMMND RPQEIGIHLA 2880 KGGLSFAKKT VFGLSDSMSK FTGSMAKGLS VTQDLEFQRV RRLQQRINKN NRNALANSAQ 2940 SFASTLGSGL SGIALDPYKA MQKEGAAGFL KGLGKGIVGL PTKTAIGFLD LTSNLSQGVK 3000 STTTVLDMQK GCRVRLPRYV DHDQIIKPYD LREAQGQYWL KTVNGGVFMN DEYLSHVILP 3060 GKELAVIVSM QHIAEVQMAT QELMWSTGYP SIQGITLERS GLQIKLKSQS EYFIPISDPE 3120 ERRSLYRNIA IAVREYNKYC EAIL 3144 |
Gene Ontology | GO:0019898; C:extrinsic to membrane; IDA:SGD. GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IDA:SGD. GO:0005628; C:prospore membrane; IDA:SGD. GO:0032120; P:ascospore-type prospore membrane assembly; IMP:SGD. GO:0045324; P:late endosome to vacuole transport; IGI:SGD. GO:0045053; P:protein retention in Golgi apparatus; IMP:SGD. GO:0006623; P:protein targeting to vacuole; IMP:SGD. |
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