CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011536
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vacuolar protein sorting-associated protein 13 
Protein Synonyms/Alias
 Suppression of the onset of impotence protein 1; Vacuolar protein-targeting protein 2 
Gene Name
 VPS13 
Gene Synonyms/Alias
 SOI1; VPT2; YLL040C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
133LSTQSENKTSSSSSEubiquitination[1]
452IEPQTSNKSATKNNGubiquitination[1]
882LQLKNTLKALENMQPubiquitination[1]
1357NSGESGGKGEIKSPSubiquitination[1]
1894DKTTEDNKNEVVLLKubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 Required for sorting signal-dependent recycling of membrane proteins between an endocytic compartment and the TGN. 
Sequence Annotation
 MOD_RES 1364 1364 Phosphoserine.
 MOD_RES 1382 1382 Phosphoserine.
 MOD_RES 1715 1715 Phosphoserine.
 MOD_RES 1729 1729 Phosphoserine.
 MOD_RES 1731 1731 Phosphoserine.  
Keyword
 Complete proteome; Golgi apparatus; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3144 AA 
Protein Sequence
MLESLAANLL NRLLGSYVEN FDPNQLNVGI WSGDVKLKNL KLRKDCLDSL NLPIDVKSGI 60
LGDLVLTVPW SSLKNKPVKI IIEDCYLLCS PRSEDHENDE EMIKRAFRLK MRKVSEWELT 120
NQARILSTQS ENKTSSSSSE KNNAGFMQSL TTKIIDNLQV TIKNIHLRYE DMDGIFTTGP 180
SSVGLTLNEL SAVSTDSNWA PSFIDITQNI THKLLTLNSL CLYWNTDSPP LISDDDQDRS 240
LENFVRGFKD MIASKNSTAP KHQYILKPVS GLGKLSINKL GSTEEQPHID LQMFYDEFGL 300
ELDDTEYNDI LHVLSSIQLR QITKKFKKAR PSFAVSENPT EWFKYIAACV INEIHEKNKM 360
WTWESMKEKC EQRRLYTKLW VEKLKLKNLE APLRDPIQEA QLSELHKDLT YDEIILFRSV 420
AKRQYAQYKL GMTEDSPTPT ASSNIEPQTS NKSATKNNGS WLSSWWNGKP TEEVDEDLIM 480
TEEQRQELYD AIEFDENEDK GPVLQVPRER VELRVTSLLK KGSFTIRKKK QNLNLGSIIF 540
ENCKVDFAQR PDSFLSSFQL NKFSLEDGSP NALYKHIISV RNSSKDQSSI DNHATGEEEE 600
EDEPLLRASF ELNPLDGLAD SNLNIKLLGM TVFYHVHFIT EVHKFFKASN QHMETIGNIV 660
NAAEATVEGW TTQTRMGIES LLEDHKTVNV SLDLQAPLII LPLDPHDWDT PCAIIDAGHM 720
SILSDLVPKE KIKEIKELSP EEYDKIDGNE INRLMFDRFQ ILSQDTQIFV GPDIQSTIGK 780
INTASSTNDF RILDKMKLEL TVDLSILPKA YKLPTIRVFG HLPRLSLSIN DIQYKTIMNL 840
IANSIPSMID DEENNGDYVN YSSGSEKEMK KQIQLQLKNT LKALENMQPL QIEQKFLELH 900
FDIDQAKIAF FQCIKNDSRN SEKLVDILCQ RLNFNFDKRA KEMNLDLRVH SLDVEDYIEL 960
TDNKEFKNLI SSGVEKVTRS QKDLFTLKYK RVQRIVPHND TLIELFDQDI VMHMSELQLV 1020
LTPRSVLTLM NYAMLTFTDP NAPEMPADVL RHNKEDRDDA PQKINMKIKM EAVNVIFNDD 1080
SIKLATLVLS AGEFTMVLLP ERYNINLKLG GLELTDETNE SFSRDSVFRK IIQMKGQELV 1140
ELSYESFDPA TNTKDYDSFL KYSTGSMHVN FIESAVNRMV NFFAKFQKSK VSFDRARLAA 1200
YNQAPSIDAV NNMKMDIVIK APIIQFPKLV GTQENNYDTM RFYLGEFFIE NKFSVIDESH 1260
KINHIKLGVR EGQLSSNLNF DGSSQQLYLV ENIGLLFNID RDPLPQDDTP ELKVTSNFES 1320
FALDLTENQL TYLLEISNKV SSAFNITDEN SGESGGKGEI KSPSPDPASL SSESERTATP 1380
QSLQGSNKSN IKNPEQKYLD FSFKAPKIAL TLYNKTKGVT SLNDCGLTRI MFQDIGCSLG 1440
LKNDGTVDGQ AHVAAFRIED VRNIKDNKHT ELIPKSKNKE YQFVANISRK NLEVGRLLNI 1500
SMTMDSPKMI LAMDYLVSLK EFFDAIMSKS HENNLYYPEN TNQKPENKAI VESVQEGGDV 1560
TKIQYSVNII ETALILLADP CDMNSEAISF KIGQFLVTDQ NIMTVAANNV GIFLFKMNSS 1620
EEKLRLLDDF SSSLTIDKRN STPQTLMTNI QLSVQPLLMR ISLRDIRLAM LIFKRVTTLL 1680
NKMTEKEDNG EEEESTDKIQ FSHEFERKLA VLDPSILGER SRASQSSDSE SIEVPTAILK 1740
NETFNADLGG LRFILIGDVH EMPILDMNVN EITASAKDWS TDFEALASLE TYVNIFNYSR 1800
SSWEPLLEMI PITFHLSKGH SEMDPAFSFD ILTQRIAEIT LSARSIAMLS HIPASLTEEL 1860
PLASRVSQKP YQLVNDTELD FDVWIQDKTT EDNKNEVVLL KANTSLPWEF EDWRSIREKL 1920
DIDKSKNILG VCVSGQNYKT IMNIDATTEG ENLHVLSPPR NNVHNRIVCE ARCDENNVKI 1980
ITFRSTLVIE NTTSTEIELL VDSKDPNKPS LKYAIKPHQS KSVPVEYAYD SDIRIRPASE 2040
DIYDWSQQTL SWKSLLSNQM SIFCSSKEDS NQRFHFEIGA KYDEREPLAK IFPHMKIVVS 2100
ASMTIENLLP ADINFSIFDK REEKRTDFLK TGESMEVHHI SLDSFLLMSV QPLQDEASAS 2160
KPSIVNTPHK SPLNPEDSLS LTLSGGQNLL LKLDYKNIDG TRSKVIRIYS PYIIMNSTDR 2220
ELYIQSSLLN IAQSKILLEN EKRYTIPKMF SFDKEDDKSN RARIRFKESE WSSKLSFDAI 2280
GQSFDASVRI KNKEQESNLG INISEGKGKY LLSKVIEIAP RYIISNTLDI PIEVCETGSM 2340
DVQQIESNIT KPLYRMRNIV DKQLVLKFLG GDSNWSQPFF IKNVGVTYLK VLKNSRHKLL 2400
KIEILLDKAT IFIRIKDGGD RWPFSIRNFS DHDFIFYQRD PRKVSDPYKD DQSNESSSRS 2460
FKPIFYRIPS KSIMPYAWDF PTAKEKYLVL ESGTRTREVR LAEIGELPPL RLDKRSKDKP 2520
APIVGLHVVA DDDMQALVIV NYKANVGLYK LKTASATTTS SVSVNSSVTD GFVQKDEDEK 2580
VNTQIVVSFK GVGISLINGR LQELLYINMR GIELRYNESK AYQTFSWKMK WMQIDNQLFS 2640
GNYSNILYPT EIPYTEKEIE NHPVISGSIS KVNDSLQAVP YFKHVTLLIQ EFSIQLDEDM 2700
LYAMMDFIKF PGSPWIMDSR DYKYDEEIQL PDVSELKTAG DIYFEIFHIQ PTVLHLSFIR 2760
SDEISPGLAE ETEESFSSSL YYVHMFAMTL GNINEAPVKV NSLFMDNVRV PLPILMDHIE 2820
RHYTTQFVYQ IHKILGSADC FGNPVGLFNT ISSGVWDLFY EPYQGYMMND RPQEIGIHLA 2880
KGGLSFAKKT VFGLSDSMSK FTGSMAKGLS VTQDLEFQRV RRLQQRINKN NRNALANSAQ 2940
SFASTLGSGL SGIALDPYKA MQKEGAAGFL KGLGKGIVGL PTKTAIGFLD LTSNLSQGVK 3000
STTTVLDMQK GCRVRLPRYV DHDQIIKPYD LREAQGQYWL KTVNGGVFMN DEYLSHVILP 3060
GKELAVIVSM QHIAEVQMAT QELMWSTGYP SIQGITLERS GLQIKLKSQS EYFIPISDPE 3120
ERRSLYRNIA IAVREYNKYC EAIL 3144 
Gene Ontology
 GO:0019898; C:extrinsic to membrane; IDA:SGD.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0005628; C:prospore membrane; IDA:SGD.
 GO:0032120; P:ascospore-type prospore membrane assembly; IMP:SGD.
 GO:0045324; P:late endosome to vacuole transport; IGI:SGD.
 GO:0045053; P:protein retention in Golgi apparatus; IMP:SGD.
 GO:0006623; P:protein targeting to vacuole; IMP:SGD. 
Interpro
 IPR011050; Pectin_lyase_fold/virulence.
 IPR026847; VPS13.
 IPR017148; VPS13_fungi.
 IPR026854; VPS13A_N.
 IPR009543; VPSAP_dom. 
Pfam
 PF12624; Chorein_N
 PF06650; DUF1162 
SMART
  
PROSITE
  
PRINTS