| Tag | Content |
|---|
| CPLM ID | CPLM-008722 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sterol O-acyltransferase 2 |
Protein Synonyms/Alias | Sterol-ester synthase 2 |
Gene Name | ARE2 |
Gene Synonyms/Alias | SAT1; YNR019W; N3206 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 18 | EQFLRIQKLNAADAG | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Ensures probably most of the acyltransferase activity. Suppression of ARE2 reduces sterol ester levels to 25% of the normal value. |
Sequence Annotation | ACT_SITE 579 579 Potential.
MOD_RES 175 175 Phosphoserine.
MOD_RES 176 176 Phosphoserine. |
Keyword | Acyltransferase; Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 642 AA |
Protein Sequence | MDKKKDLLEN EQFLRIQKLN AADAGKRQSI TVDDEGELYG LDTSGNSPAN EHTATTITQN 60
HSVVASNGDV AFIPGTATEG NTEIVTEEVI ETDDNMFKTH VKTLSSKEKA RYRQGSSNFI 120
SYFDDMSFEH RPSILDGSVN EPFKTKFVGP TLEKEIRRRE KELMAMRKNL HHRKSSPDAV 180
DSVGKNDGAA PTTVPTAATS ETVVTVETTI ISSNFSGLYV AFWMAIAFGA VKALIDYYYQ 240
HNGSFKDSEI LKFMTTNLFT VASVDLLMYL STYFVVGIQY LCKWGVLKWG TTGWIFTSIY 300
EFLFVIFYMY LTENILKLHW LSKIFLFLHS LVLLMKMHSF AFYNGYLWGI KEELQFSKSA 360
LAKYKDSIND PKVIGALEKS CEFCSFELSS QSLSDQTQKF PNNISAKSFF WFTMFPTLIY 420
QIEYPRTKEI RWSYVLEKIC AIFGTIFLMM IDAQILMYPV AMRALAVRNS EWTGILDRLL 480
KWVGLLVDIV PGFIVMYILD FYLIWDAILN CVAELTRFGD RYFYGDWWNC VSWADFSRIW 540
NIPVHKFLLR HVYHSSMSSF KLNKSQATLM TFFLSSVVHE LAMYVIFKKL RFYLFFFQML 600
QMPLVALTNT KFMRNRTIIG NVIFWLGICM GPSVMCTLYL TF 642 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IDA:SGD. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; ISM:SGD. GO:0034736; F:cholesterol O-acyltransferase activity; IEA:EC. GO:0034737; F:ergosterol O-acyltransferase activity; IMP:SGD. GO:0008204; P:ergosterol metabolic process; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |