UniProt Accession

 MRRP3_HUMAN; O15091; B4DXD9; B4E0S8; B4E211; C4AM93; D3DS99; D3DSA1; Q86SZ4; Q86YB5; Q8N5L5 

Genbank Protein ID

 AB002389; BX161394; BX161487; AK301931; AK303508; AK304066; AL121594; CH471078; CH471078; CH471078; CH471078; CH471078; CH471078; CH471078; BC032221; BC044580 

Genbank Nucleotide ID

 BAA20845.2; CAD61881.1; CAD61937.1; BAG63351.1; BAG64540.1; BAG64973.1; EAW65878.1; EAW65882.1; EAW65879.1; EAW65880.1; EAW65881.1; EAW65883.1; EAW65884.1; AAH32221.1; AAH44580.1 

Protein Name

 Mitochondrial ribonuclease P protein 3 

Protein Synonyms/Alias

 Mitochondrial RNase P protein 3 

Gene Name

 KIAA0391 

Gene Synonyms/Alias

 MRPP3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
91	FFLAGAAKERSQMNS	ubiquitination	[1, 2]
512	KACLPDAKTQRLFFK	acetylation	[3, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Mitochondrion; Polymorphism; Reference proteome; Transit peptide; tRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 583 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR026318; MRPP3. 

Pfam

  

SMART

  

PROSITE

  

PRINTS