CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042430
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 HEAT repeat-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 HEATR2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43VIHFGNGKSVDDVLSubiquitination[1]
120DVGLQWQKENEEDLKubiquitination[2]
161LVFRNLSKILPALCHubiquitination[1]
180WVVGTRVKSAQLLPVubiquitination[1]
247KLILSTLKKTPSASGubiquitination[2]
248LILSTLKKTPSASGLubiquitination[1]
363SCQDLYRKHIGPLLEubiquitination[1, 2, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 657 AA 
Protein Sequence
XSPPCAARAA AAPPPWRRPR PHWKVRVAAI EATGAVIHFG NGKSVDDVLS HFAQRLFDDV 60
PQVRRAVASV VGGWLLCLRD RYSFFHKLIP LLLSSLNDEV PEVRQLAASL WEDVGLQWQK 120
ENEEDLKDKL DFAPPTPPHY PPHERRPVLG CRELVFRNLS KILPALCHDI TDWVVGTRVK 180
SAQLLPVLLL HAEDHATQHL EVVLRTLFQA CTDEEAAVVQ SCTRSAELVG TFVSPEVFLK 240
LILSTLKKTP SASGLLVLAS AMRGCPREAL QPHLAAIATE LAQAHICQAS ENDLYLERLL 300
LCVQALVSVC HEDCGVASLQ LLDVLLTIVA LAGATGLRDK AQETMDSLAM VEGVSSCQDL 360
YRKHIGPLLE RVTASHLDWT AHSPELLQFS VIVAQSGPAL GEALPHVVPT LRACLQPSQD 420
PQMRLKLFSI LSTVLLRATD TINSQGQFPS YLETVTKDIL APNLQWHAGR TAAAIRTAAV 480
SCLWALTSSE VLSAEQIRDV QETLMPQVLT TLEEDSKMTR LISCRIINTF LKTSGGMTDP 540
EKLIRIYPEL LKRLDDVSND VRMAAASTLV TWLQCVKGAN AKSYYQSSVQ YLYRELLVHL 600
DDPERAIQDA ILEVLKEGSG LFPDLLVRET EAVIHKHRSA TYCEQLLQHV QAVPATQ 657 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000357; HEAT.
 IPR021133; HEAT_type_2. 
Pfam
 PF02985; HEAT 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS