UniProt Accession

 SSBP1_YEAST; P10080; D3DKT4 

Genbank Protein ID

 M17244; U11583; X66278; BK006934 

Genbank Nucleotide ID

 AAA35098.1; AAB65046.1; CAA46989.1; DAA06651.1 

Protein Name

 Single-stranded nucleic acid-binding protein 

Protein Synonyms/Alias

  

Gene Name

 SBP1 

Gene Synonyms/Alias

 SSB1; SSBR1; YHL034C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
99	KIDFDNIKENYDTKV	acetylation	[1]
99	KIDFDNIKENYDTKV	ubiquitination	[2]
175	FNGQKREKIPLDQME	ubiquitination	[2]
196	YINNVPFKATKEEVA	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Functions in the transition of mRNAs from translation to an mRNP complex destined for decapping. High-copy-number suppressor of decapping defects. Overexpression suppresses decapping defects in both DCP1-2 and DCP2-7 mutations. Acts to promote translational repression of mRNA in conjunction with DHH1 and subsequent mRNA localization to P bodies. Promotes translational repression of mRNA during glucose deprivation. 

Sequence Annotation

 DOMAIN 37 119 RRM 1.
 DOMAIN 186 274 RRM 2.
 REGION 131 151 RNA-binding RGG-box (By similarity).
 MOD_RES 91 91 Phosphothreonine.
 MOD_RES 119 119 Phosphothreonine.  

Keyword

 Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 294 AA 

Protein Sequence

Gene Ontology

 GO:0000932; C:cytoplasmic mRNA processing body; IDA:SGD.
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0031370; F:eukaryotic initiation factor 4G binding; IDA:SGD.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; ISS:SGD.
 GO:0032055; P:negative regulation of translation in response to stress; IMP:SGD. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS