CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019996
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Reticulon-4 
Protein Synonyms/Alias
 Neurite outgrowth inhibitor; Nogo protein 
Gene Name
 Rtn4 
Gene Synonyms/Alias
 Kiaa0886; Nogo 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
371REEYADFKPFEQAWEacetylation[1]
1074GHVNSTIKELRRLFLubiquitination[2]
1141HYLGLANKSVKDAMAubiquitination[2]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing. 
Sequence Annotation
 DOMAIN 975 1162 Reticulon.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 7 7 Phosphoserine (By similarity).
 MOD_RES 16 16 Phosphoserine.
 MOD_RES 105 105 Phosphoserine.
 MOD_RES 145 145 Phosphoserine.
 MOD_RES 165 165 Phosphoserine.
 MOD_RES 171 171 Phosphothreonine.
 MOD_RES 344 344 Phosphoserine.
 MOD_RES 426 426 Phosphoserine.
 MOD_RES 690 690 Phosphoserine.
 MOD_RES 836 836 Phosphoserine.
 MOD_RES 839 839 Phosphoserine.
 MOD_RES 857 857 Phosphoserine.
 MOD_RES 861 861 Phosphotyrosine.
 MOD_RES 1074 1074 N6-acetyllysine (By similarity).  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Membrane; Neurogenesis; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1162 AA 
Protein Sequence
MEDIDQSSLV SSSADSPPRP PPAFKYQFVT EPEDEEDEED EEEEEDDEDL EELEVLERKP 60
AAGLSAAPVP PAAAPLLDFS SDSVPPAPRG PLPAAPPTAP ERQPSWERSP AASAPSLPPA 120
AAVLPSKLPE DDEPPARPPA PAGASPLAEP AAPPSTPAAP KRRGSGSVDE TLFALPAASE 180
PVIPSSAEKI MDLKEQPGNT VSSGQEDFPS VLFETAASLP SLSPLSTVSF KEHGYLGNLS 240
AVASTEGTIE ETLNEASREL PERATNPFVN RESAEFSVLE YSEMGSSFNG SPKGESAMLV 300
ENTKEEVIVR SKDKEDLVCS AALHNPQESP ATLTKVVKED GVMSPEKTMD IFNEMKMSVV 360
APVREEYADF KPFEQAWEVK DTYEGSRDVL AARANMESKV DKKCFEDSLE QKGHGKDSES 420
RNENASFPRT PELVKDGSRA YITCDSFSSA TESTAANIFP VLEDHTSENK TDEKKIEERK 480
AQIITEKTSP KTSNPFLVAI HDSEADYVTT DNLSKVTEAV VATMPEGLTP DLVQEACESE 540
LNEATGTKIA YETKVDLVQT SEAIQESIYP TAQLCPSFEE AEATPSPVLP DIVMEAPLNS 600
LLPSTGASVA QPSASPLEVP SPVSYDGIKL EPENPPPYEE AMSVALKTSD SKEEIKEPES 660
FNAAAQEAEA PYISIACDLI KETKLSTEPS PEFSNYSEIA KFEKSVPDHC ELVDDSSPES 720
EPVDLFSDDS IPEVPQTQEE AVMLMKESLT EVSETVTQHK HKERLSASPQ EVGKPYLESF 780
QPNLHITKDA ASNEIPTLTK KETISLQMEE FNTAIYSNDD LLSSKEDKMK ESETFSDSSP 840
IEIIDEFPTF VSAKDDSPKE YTDLEVSNKS EIANVQSGAN SLPCSELPCD LSFKNTYPKD 900
EAHVSDEFSK SRSSVSKVPL LLPNVSALES QIEMGNIVKP KVLTKEAEEK LPSDTEKEDR 960
SLTAVLSAEL NKTSVVDLLY WRDIKKTGVV FGASLFLLLS LTVFSIVSVT AYIALALLSV 1020
TISFRIYKGV IQAIQKSDEG HPFRAYLESE VAISEELVQK YSNSALGHVN STIKELRRLF 1080
LVDDLVDSLK FAVLMWVFTY VGALFNGLTL LILALISLFS IPVIYERHQA QIDHYLGLAN 1140
KSVKDAMAKI QAKIPGLKRK AE 1162 
Gene Ontology
 GO:0042995; C:cell projection; IDA:MGI.
 GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0005635; C:nuclear envelope; ISS:UniProtKB.
 GO:0001525; P:angiogenesis; IMP:MGI.
 GO:0007413; P:axonal fasciculation; IMP:UniProtKB.
 GO:0060317; P:cardiac epithelial to mesenchymal transition; IMP:MGI.
 GO:0021801; P:cerebral cortex radial glia guided migration; IMP:UniProtKB.
 GO:0071786; P:endoplasmic reticulum tubular network organization; IEA:Compara.
 GO:0030517; P:negative regulation of axon extension; IMP:UniProtKB.
 GO:2000172; P:regulation of branching morphogenesis of a nerve; IMP:UniProtKB.
 GO:0030334; P:regulation of cell migration; IEA:Compara. 
Interpro
 IPR003388; Reticulon. 
Pfam
 PF02453; Reticulon 
SMART
  
PROSITE
 PS50845; RETICULON 
PRINTS