CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040440
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Adenylate kinase 2, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Ak2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
11ASEPEIPKGIRAVLLacetylation[1, 2]
25LGPPGAGKGTQAPKLubiquitination[3]
31GKGTQAPKLAENFCVacetylation[2]
59ASGSELGKKLKATMDacetylation[4, 5]
59ASGSELGKKLKATMDsuccinylation[5]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 72 AA 
Protein Sequence
NVLASEPEIP KGIRAVLLGP PGAGKGTQAP KLAENFCVCH LATGDMLRAM VASGSELGKK 60
LKATMDAGKL VY 72 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0097226; C:sperm mitochondrial sheath; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0019205; F:nucleobase-containing compound kinase activity; IEA:InterPro.
 GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro. 
Interpro
 IPR000850; Adenylate_kin.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00406; ADK 
SMART
  
PROSITE
  
PRINTS
 PR00094; ADENYLTKNASE.