CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044384
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Guanylate cyclase soluble subunit alpha-3 
Protein Synonyms/Alias
  
Gene Name
 GUCY1A3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
348NNVTLANKFESCSVPubiquitination[1]
357ESCSVPRKINVSPTTubiquitination[1]
369PTTYRLLKDCPGFVFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lyase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 432 AA 
Protein Sequence
MKSTKPSLSP SKPQSSLVIP TSLFCKTFPF HFMFDKDMTI LQFGNGIRRL MNRRDFQGKP 60
NFEEYFEILT PKINQTFSGI MTMLNMQFVV RVRRWDNSVK KSSRVMDLKG QMIYIVESSA 120
ILFLGSPCVD RLEDFTGRGL YLSDIPIHNA LRDVVLIGEQ ARAQDGLKKR LGKLKATLEQ 180
AHQALEEEKK KTVDLLCSIF PCEVAQQLWQ GQVVQAKKFS NVTMLFSDIV GFTAICSQCS 240
PLQVITMLNA LYTRFDQQCG ELDVYKVETI GDAYCVAGGL HKESDTHAVQ IALMALKMME 300
LSDEVMSPHG EPIKMRIGLH SGSVFAGVVG VKMPRYCLFG NNVTLANKFE SCSVPRKINV 360
SPTTYRLLKD CPGFVFTPRS REELPPNFPS EIPGICHFLD AYQQGTNSKP CFQKKDVEDG 420
NANFLGKASG ID 432 
Gene Ontology
 GO:0004383; F:guanylate cyclase activity; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0030828; P:positive regulation of cGMP biosynthetic process; IEA:Compara.
 GO:0008217; P:regulation of blood pressure; IEA:Compara.
 GO:0060087; P:relaxation of vascular smooth muscle; IEA:Compara.
 GO:0052565; P:response to defense-related host nitric oxide production; IEA:Compara. 
Interpro
 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS.
 IPR011645; Haem_no_assoc-bd. 
Pfam
 PF00211; Guanylate_cyc
 PF07701; HNOBA 
SMART
 SM00044; CYCc 
PROSITE
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2 
PRINTS