UniProt Accession

 ETV4_MOUSE; P28322 

Genbank Protein ID

 X63190 

Genbank Nucleotide ID

 CAA44872.1 

Protein Name

 ETS translocation variant 4 

Protein Synonyms/Alias

 Polyomavirus enhancer activator 3; Protein PEA3 

Gene Name

 Etv4 

Gene Synonyms/Alias

 Pea-3; Pea3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
171	HSPTTRIKKEPQSPR	sumoylation	[1]
297	PYPQQNFKQEYHDPL	sumoylation	[1]
331	PGAGVVIKQERTDFA	sumoylation	[1]
393	KKFEGDIKQEGIGAF	sumoylation	[1]

Reference

 [1] The transactivation function of the Pea3 subfamily Ets transcription factors is regulated by sumoylation.
 Bojović BB, Hassell JA.
 DNA Cell Biol. 2008 Jun;27(6):289-305. [PMID: 18447755] 

Functional Description

 Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'. May play a regulatory role during embryogenesis. 

Sequence Annotation

 DNA_BIND 412 492 ETS.
 CROSSLNK 171 171 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 297 297 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 331 331 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Activator; Complete proteome; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 555 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IDA:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0060444; P:branching involved in mammary gland duct morphogenesis; IMP:MGI.
 GO:0008045; P:motor neuron axon guidance; IMP:MGI.
 GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IMP:MGI.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IDA:MGI.
 GO:0048863; P:stem cell differentiation; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000418; Ets_dom.
 IPR006715; ETS_PEA3_N.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00178; Ets
 PF04621; ETS_PEA3_N 

SMART

 SM00413; ETS 

PROSITE

 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3 

PRINTS

 PR00454; ETSDOMAIN.