| Tag | Content |
|---|
| CPLM ID | CPLM-015857 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrator complex subunit 7 |
Protein Synonyms/Alias | Int7 |
Gene Name | Ints7 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 105 | LNVDEFVKRVFSVIH | ubiquitination | [1] | | 867 | SKSGQDYKIPIDSMT | ubiquitination | [1] | | 929 | PRTTMFVKSLEDPYS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase (By similarity). |
Sequence Annotation | MOD_RES 525 525 Phosphothreonine.
MOD_RES 527 527 Phosphotyrosine. |
Keyword | Alternative splicing; Chromosome; Complete proteome; DNA damage; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 966 AA |
Protein Sequence | MASNSTKSFL ADAGYGEQEL DANSALMELD KGLRSGKLGE QCEAVVRFPR LFQKYPFPIL 60
INSAFLKLAD VFRVGNNFLR LCVLKVTQQS EKHLEKILNV DEFVKRVFSV IHSNDPVARA 120
ITLRMLGSLA SIIPERKNAH HSIRQSLDSH DNVEVEAAVF AAANFSAQSK DFAVGICNKI 180
SEMIQGLATP VDLKLKLIPI LQHMHHDALL ASSARQLLQQ LVTSYPSTKM VIVSLHTFTL 240
LAASSLVDTP KQIQLLLQYL KNDPRKAVKR LAVQDLKLLA SKTPHTWSKE NIQALCECAL 300
HTPYDSLKLG MLSVLSTLSG TIAIKHYFSV VPGNVGSSPR SSDLVKLAQE CCYHSNRGIA 360
AHGVRVLTNI TVSCQEKDLL SLEQDAVFGL ESLLVLCSQD DSPGAQSTVK SALSCMVKLA 420
KGRPHLSRSV VDTLLTQLHS SQDAARILMC HCLAAIAMQL PVLGDGMLGD LVELYKVIGR 480
SATDKQQELL VSLATVIFVA SQKALSAEVK AVIKQQLESV SSGWTVYRIA RQASRMGNHD 540
MARELYQSLL TQVASEHFYF WLNSLKEFSH AEQCLTGLQE DSFSSALSCI AESLKFYHKG 600
IASLTAASTP LNPLSFQCEF VKLRIDLLQA FSQLICTCNS LKTSPPPAIA TTIAMTLGND 660
LQRCGRISNQ MKQSMEEFRS LASRYRDLYQ ASFDADSATL RNVELQQQSC LLIAHAIEAL 720
VLDPESASFQ EYGSTGAAHA DSEYERRMMS VYSRVLEEVE SLNRKYAPVS YMHTACLCNA 780
IIALLKVPLS FQRYFFQKLQ STSIKLALSP SPRSPAEPIA VQNNQQLALK VEGVVQHGSK 840
PGLFRRVQSV CLNVSSTLQS KSGQDYKIPI DSMTNEMEQR VEPHNDYFST QFLLNFAVLG 900
THSITVESSV RDANGIVWKT GPRTTMFVKS LEDPYSQQIR LQQQAQQPLQ PQPLPQPQPR 960
SAYTRF 966 |
Gene Ontology | GO:0005694; C:chromosome; IEA:UniProtKB-SubCell. GO:0032039; C:integrator complex; ISS:HGNC. GO:0071479; P:cellular response to ionizing radiation; IEA:Compara. GO:0000077; P:DNA damage checkpoint; IEA:Compara. GO:0016180; P:snRNA processing; ISS:HGNC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |