UniProt Accession

 EAF6_HUMAN; Q9HAF1; B1AK64; Q4F967; Q7Z311; Q86WE3 

Genbank Protein ID

 BX538212; BX640719; AK021792; DQ099384; AL034379; AL034379; BC056406; BC016328; AY211926 

Genbank Nucleotide ID

 CAD98071.1; CAE45838.1; BAB13898.1; AAZ13760.1; CAI20549.1; CAI20550.1; AAH56406.1; AAH16328.1; AAO65179.1 

Protein Name

 Chromatin modification-related protein MEAF6 

Protein Synonyms/Alias

 MYST/Esa1-associated factor 6; Esa1-associated factor 6 homolog; Protein EAF6 homolog; hEAF6; Sarcoma antigen NY-SAR-91 

Gene Name

 MEAF6 

Gene Synonyms/Alias

 C1orf149; EAF6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	RELAELVKRKQELAE	ubiquitination	[1]
26	LAELVKRKQELAETL	ubiquitination	[1, 2]
113	VQDQLIEKREPGSGT	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. 

Sequence Annotation

 MOD_RES 69 69 N6-acetyllysine.
 MOD_RES 74 74 N6-acetyllysine.
 MOD_RES 118 118 Phosphoserine.
 MOD_RES 120 120 Phosphothreonine.  

Keyword

 Acetylation; Activator; Alternative splicing; Chromatin regulator; Chromosomal rearrangement; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 191 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0070776; C:MOZ/MORF histone acetyltransferase complex; IDA:UniProtKB.
 GO:0035267; C:NuA4 histone acetyltransferase complex; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0043968; P:histone H2A acetylation; IDA:UniProtKB.
 GO:0044154; P:histone H3-K14 acetylation; IDA:UniProtKB.
 GO:0043983; P:histone H4-K12 acetylation; IDA:UniProtKB.
 GO:0043981; P:histone H4-K5 acetylation; IDA:UniProtKB.
 GO:0043982; P:histone H4-K8 acetylation; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR015418; Hist_AcTrfase_NuA4_cplx. 

Pfam

 PF09340; NuA4 

SMART

  

PROSITE

  

PRINTS