| Tag | Content |
|---|
| CPLM ID | CPLM-015618 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Synemin |
Protein Synonyms/Alias | Desmuslin |
Gene Name | Synm |
Gene Synonyms/Alias | Dmn; Kiaa0353 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 12 | RLQTGSEKAELQELN | ubiquitination | [1] | | 1128 | SQSVRHVKLGPTEMW | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells (By similarity). |
Sequence Annotation | REGION 1 10 Head.
REGION 11 320 Interaction with DMD and UTRN (By
REGION 11 300 Rod.
REGION 11 49 Coil 1A.
REGION 50 58 Linker 1.
REGION 59 163 Coil 1B.
REGION 164 186 Linker 12.
REGION 187 300 Coil 2.
REGION 301 1561 Tail.
REGION 1152 1453 Interaction with TLN1 and VCL (By
REGION 1242 1557 Interaction with DMD and UTRN (By
MOD_RES 599 599 Phosphoserine.
MOD_RES 1044 1044 Phosphoserine (By similarity).
MOD_RES 1049 1049 Phosphoserine.
MOD_RES 1179 1179 Phosphoserine (By similarity).
MOD_RES 1182 1182 Phosphoserine (By similarity).
MOD_RES 1425 1425 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Cell junction; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Intermediate filament; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1561 AA |
Protein Sequence | MLSWRLQTGS EKAELQELNA RLYDYVCRVR ELERENLLLE EELRSRLSRE DRWAEDQALY 60
AEEARSLRQQ LDELNWSTAL AEGERDALRR ELLELQREGV EAGTARSRLD AELGAQRREL 120
EEALGARAAL EALLGRLETE RRDLDAAHER QVRDLRARAA SLTMHFRARA TSPAAPPPRL 180
RDVHDSYALL VAESWRESVQ LYEDEVRELE QALRRGQESR LQAEDEARLC AQEADALRNQ 240
ALELEQLRAR LEDELLRMRE EYGMQAEERQ RVIDSLEDEK EALTLAMADR LRDYQELLQV 300
KTGLSLEVAT YRALLEGESN PEILIWTENI ENVPQEPRNT SYRYTNSVLQ RKNEKNLFPR 360
RKTPWAAVNH SSASYSNWPG HLDSQTTTAV GSAARRGLLT SRHSSSATTS GQQKPLEKTI 420
SSRANLRPVT PTHGFLRNTD AQMKTLPHRS KVEGTGDTHA RRATESVITR ESYRGHQGHV 480
AAGAVSSTPS NERTVILGKK LEAQATKEQE RDRSGVIRIK PEEKMFDSKE KASEERNLRW 540
EELTKLDRDA RKRESRHLRD EAREKEALKE RSVKEREVPI SLEVSRGSRA EVSTIHLQSP 600
GRKDVSHSGG REAETKETRF RLDTQDTASS LQSDSTTETI AESIVTTILK QFTQSPGAEE 660
EATSFPDTKV TYVDRKEFPG DGKTKTEIVV ESKLTDVVDV SDEAGLDYLL SKDVKEVGLK 720
GKSTETMIGE MINLGLKGRE GRAKVVNVEI VEEPMSYIGG GKIDFSTPFQ VEEVDDVSPS 780
PKGFVEEEDG EGETHMAFSM RPHQTKQPQG TIPHVEEVTE AGDSEGEQSY FVSTPDEYPG 840
GHDREDDGSV YGQIHIEEES TIRYSWQDEI AQGTWRRKMR GDVGGEKPVK VLEVPALSLG 900
GAIGSAHLKE EASGELRAEP TVIEKEIKIP HEFHTSIKGV FSSEPRHQLV EVIGQLEETL 960
PERMKEELSA LTRQSQGESG SVSVDVKKVQ SAAGGSVTLM AEVNLSQTVD ADQLDLEQLS 1020
RDEAGEIERA VESVVRESLA KRSSPVPRSP DREDGEEVPA GGILFKRWAT RELYSPSGER 1080
DDAGQVSPSS DQRVTQGPVS ATVEVTSPTG FVQSHVLEDV SQSVRHVKLG PTEMWRTEQV 1140
TFGGPTAQVV EVSGDFSEAV SSEGASRSVR HITLGPHQSQ VSTEVIFRGS VPTWQETGDT 1200
EKPGPVVLSV GADISGSGRM PGSERSHTEK EIRFQGPVSG TAQVGGNFAT EESVGSQTFV 1260
RSLQLGPKEG FREEIQFIAP IPDKVGWGEE DSEHTKVSLE RATSIQRIDI VPQRYLASKQ 1320
MAPQTLEFRD SEDMVMVEGS AGTIQATHNF TSDREILQNK ENTFQRVISG SPPDSVGDTG 1380
AEVTANVSRS FRHIQIGPTE EEPSEYFVTG RPVSKTFVLD GSVASPGLVG GADGGSTPCR 1440
IALGPKETSF TFQMDLSDTR AIRSWTRDTG SEVEAHGVSH RGGWRIAHSR DERVASTGSG 1500
ASPGDAHQAP GEKGTEQAGF DKTVQLQRMV DQRSVASDEK KVALLYLDNE EEEEEEGEGW 1560
F 1561 |
Gene Ontology | GO:0005912; C:adherens junction; ISS:UniProtKB. GO:0043034; C:costamere; ISS:UniProtKB. GO:0005882; C:intermediate filament; ISS:UniProtKB. GO:0016020; C:membrane; IDA:MGI. GO:0060053; C:neurofilament cytoskeleton; IDA:MGI. GO:0019215; F:intermediate filament binding; IDA:UniProtKB. GO:0005200; F:structural constituent of cytoskeleton; ISS:UniProtKB. GO:0008307; F:structural constituent of muscle; ISS:UniProtKB. GO:0017166; F:vinculin binding; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |