| Tag | Content |
|---|
| CPLM ID | CPLM-014566 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pikachurin |
Protein Synonyms/Alias | Agrin-like protein; EGF-like, fibronectin type-III and laminin G-like domain-containing protein |
Gene Name | EGFLAM |
Gene Synonyms/Alias | AGRINL; AGRNL |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 289 | ATKGGNKKFLVESKK | ubiquitination | [1, 2] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity). |
Sequence Annotation | DOMAIN 34 133 Fibronectin type-III 1.
DOMAIN 141 237 Fibronectin type-III 2.
DOMAIN 343 381 EGF-like 1.
DOMAIN 386 564 Laminin G-like 1.
DOMAIN 565 602 EGF-like 2.
DOMAIN 609 788 Laminin G-like 2.
DOMAIN 784 820 EGF-like 3.
DOMAIN 835 1014 Laminin G-like 3.
CARBOHYD 47 47 N-linked (GlcNAc...) (Potential).
DISULFID 347 358 By similarity.
DISULFID 352 369 By similarity.
DISULFID 371 380 By similarity.
DISULFID 534 564 By similarity.
DISULFID 569 580 By similarity.
DISULFID 574 590 By similarity.
DISULFID 592 601 By similarity.
DISULFID 788 799 By similarity.
DISULFID 793 808 By similarity.
DISULFID 810 819 By similarity.
DISULFID 987 1014 By similarity. |
Keyword | Alternative splicing; Cell junction; Complete proteome; Direct protein sequencing; Disulfide bond; EGF-like domain; Extracellular matrix; Glycoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Synapse. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1017 AA |
Protein Sequence | MDLIRGVLLR LLLLASSLGP GAVSLRAAIR KPGKVGPPLD IKLGALNCTA FSIQWKMPRH 60
PGSPILGYTV FYSEVGADKS LQEQLHSVPL SRDIPTTEEV IGDLKPGTEY RVSIAAYSQA 120
GKGRLSSPRH VTTLSQDSCL PPAAPQQPHV IVVSDSEVAL SWKPGASEGS APIQYYSVEF 180
IRPDFDKKWT SIHERIQMDS MVIKGLDPDT NYQFAVRAMN SHGPSPRSWP SDIIRTLCPE 240
EAGSGRYGPR YITDMGAGED DEGFEDDLDL DISFEEVKPL PATKGGNKKF LVESKKMSIS 300
NPKTISRLIP PTSASLPVTT VAPQPIPIQR KGKNGVAIMS RLFDMPCDET LCSADSFCVN 360
DYTWGGSRCQ CTLGKGGESC SEDIVIQYPQ FFGHSYVTFE PLKNSYQAFQ ITLEFRAEAE 420
DGLLLYCGEN EHGRGDFMSL AIIRRSLQFR FNCGTGVAII VSETKIKLGG WHTVMLYRDG 480
LNGLLQLNNG TPVTGQSQGQ YSKITFRTPL YLGGAPSAYW LVRATGTNRG FQGCVQSLAV 540
NGRRIDMRPW PLGKALSGAD VGECSSGICD EASCIHGGTC TAIKADSYIC LCPLGFKGRH 600
CEDAFTLTIP QFRESLRSYA ATPWPLEPQH YLSFMEFEIT FRPDSGDGVL LYSYDTGSKD 660
FLSINLAGGH VEFRFDCGSG TGVLRSEDPL TLGNWHELRV SRTAKNGILQ VDKQKIVEGM 720
AEGGFTQIKC NTDIFIGGVP NYDDVKKNSG VLKPFSGSIQ KIILNDRTIH VKHDFTSGVN 780
VENAAHPCVR APCAHGGSCR PRKEGYDCDC PLGFEGLHCQ KECGNYCLNT IIEAIEIPQF 840
IGRSYLTYDN PDILKRVSGS RSNVFMRFKT TAKDGLLLWR GDSPMRPNSD FISLGLRDGA 900
LVFSYNLGSG VASIMVNGSF NDGRWHRVKA VRDGQSGKIT VDDYGARTGK SPGMMRQLNI 960
NGALYVGGMK EIALHTNRQY MRGLVGCISH FTLSTDYHIS LVEDAVDGKN INTCGAK 1017 |
Gene Ontology | GO:0005604; C:basement membrane; IEA:Compara. GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0005614; C:interstitial matrix; IEA:Compara. GO:0045202; C:synapse; IEA:UniProtKB-SubCell. GO:0005539; F:glycosaminoglycan binding; IEA:Compara. GO:0030198; P:extracellular matrix organization; IEA:Compara. GO:0019800; P:peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; IEA:Compara. GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |