CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016436
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein DENND6A 
Protein Synonyms/Alias
 DENN domain-containing protein 6A 
Gene Name
 Dennd6a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
466QKSISPWKSPPQLRQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes (By similarity). 
Sequence Annotation
 MOD_RES 124 124 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Endosome; Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 605 AA 
Protein Sequence
MALPGPAVFG PGSRGSLDEA GAEGREAAAL AAAGVALEDE EEDDGRRGLL RWDGFSAWLH 60
CVCVVGFDLE LGQAVEVIYP QHSKLTDKEK TNICYLSFPD SNSGCLGDTQ FCFRFRQSSG 120
RRVSLHCLLD EFDKDLPVYL KKDPAYFYGY VYFRQVRDKT LKRGYFQKSL VLISKLPYIH 180
FFHTVLKQIA PEYFEKNEPY LEAACNDVDR WPAPVPGKTL HLPIMGLVMK VRIPTCHDKP 240
GTTQMVQLTQ QADTHTSIIL PTVHEVDLFR CFCPVFLHSQ MLWELVLLGE PLVVMAPSPS 300
ESSETVLALV NCISPLKYFS DFRPYFTIHD SEFKEYTTRT QAPPSVILGV TNPFFAKTLQ 360
HWPHIIRIGD LKPAGEIPKQ VKVKKLKNLK TLDSKPGVYT SYKPYLNRDE EIIKQLQKGI 420
QQKRPSEAQS VILRRYFLEL TQSFIIPLER YVASLMPLQK SISPWKSPPQ LRQFLPEEFM 480
KTLEKTGPQL TSGIKGDWIG LYRQFLKSPN FDGWFKTRRK EMTQKLEALH LEALCEEVRK 540
KCISTCKCSE YKSILRGLE 559 
Gene Ontology
 GO:0055037; C:recycling endosome; ISS:UniProtKB.
 GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
 GO:2000049; P:positive regulation of cell-cell adhesion mediated by cadherin; ISS:UniProtKB. 
Interpro
 IPR012860; Afi1_N.
 IPR024224; Uncharacterised_FAM116. 
Pfam
 PF07792; Afi1 
SMART
  
PROSITE
  
PRINTS