UniProt Accession

 TKT_MYCPN; P75611 

Genbank Protein ID

 U00089 

Genbank Nucleotide ID

 AAB95721.1 

Protein Name

 Transketolase 

Protein Synonyms/Alias

 TK 

Gene Name

 tkt 

Gene Synonyms/Alias

 tktA; MPN_082; MP073 

Created Date

 July 27, 2013 

Organism

 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 

NCBI Taxa ID

 272634 

Lysine Modification

Position	Peptide	Type	References
133	RVLAAEFKALSPKLF	acetylation	[1]
259	HWFIPTDKDFARFNS	acetylation	[1]
306	AYKELLEKLKDKPLY	acetylation	[1]
641	FNVTNLLKLIKTLKS	acetylation	[1]

Reference

 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 

Functional Description

 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity). 

Sequence Annotation

 NP_BIND 109 111 Thiamine pyrophosphate (By similarity).
 ACT_SITE 397 397 Proton donor (By similarity).
 METAL 150 150 Magnesium (By similarity).
 METAL 180 180 Magnesium (By similarity).
 METAL 182 182 Magnesium; via carbonyl oxygen (By
 BINDING 22 22 Substrate (By similarity).
 BINDING 62 62 Thiamine pyrophosphate (By similarity).
 BINDING 151 151 Thiamine pyrophosphate; via amide
 BINDING 180 180 Thiamine pyrophosphate (By similarity).
 BINDING 252 252 Substrate (By similarity).
 BINDING 252 252 Thiamine pyrophosphate (By similarity).
 BINDING 345 345 Substrate (By similarity).
 BINDING 372 372 Substrate (By similarity).
 BINDING 423 423 Thiamine pyrophosphate (By similarity).
 BINDING 447 447 Substrate (By similarity).
 BINDING 455 455 Substrate (By similarity).
 BINDING 506 506 Substrate (By similarity).  

Keyword

 Calcium; Complete proteome; Magnesium; Metal-binding; Reference proteome; Thiamine pyrophosphate; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 648 AA 

Protein Sequence

Gene Ontology

 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004802; F:transketolase activity; IEA:EC. 

Interpro

 IPR009014; Transketo_C/Pyr-ferredox_oxred.
 IPR015941; Transketolase-like_C.
 IPR005475; Transketolase-like_Pyr-bd.
 IPR005478; Transketolase_bac-like.
 IPR020826; Transketolase_BS.
 IPR005474; Transketolase_N. 

Pfam

 PF02779; Transket_pyr
 PF00456; Transketolase_N 

SMART

 SM00861; Transket_pyr 

PROSITE

 PS00801; TRANSKETOLASE_1
 PS00802; TRANSKETOLASE_2 

PRINTS