UniProt Accession

 GLMM_ECOLI; P31120; Q2M936 

Genbank Protein ID

 L12968; U01376; U18997; U00096; AP009048 

Genbank Nucleotide ID

 AAA16122.1; AAA97510.1; AAA57977.1; AAC76208.1; BAE77220.1 

Protein Name

 Phosphoglucosamine mutase 

Protein Synonyms/Alias

  

Gene Name

 glmM 

Gene Synonyms/Alias

 mrsA; yhbF; b3176; JW3143 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
5	***MSNRKYFGTDGI	acetylation	[1]
35	KLGWAAGKVLARHGS	acetylation	[1]
49	SRKIIIGKDTRISGY	acetylation	[1]
135	AIEAEMEKEISCVDS	acetylation	[2]
147	VDSAELGKASRIVDA	acetylation	[1]
314	GDRYVLEKMQEKGWR	acetylation	[1, 2, 3]
318	VLEKMQEKGWRIGAE	acetylation	[1]
367	HDLCSGMKMFPQILV	acetylation	[1]
392	PLEHESVKAVTAEVE	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [3] The diversity of lysine-acetylated proteins in Escherichia coli.
 Yu BJ, Kim JA, Moon JH, Ryu SE, Pan JG.
 J Microbiol Biotechnol. 2008 Sep;18(9):1529-36. [PMID: 18852508] 

Functional Description

 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. Can also catalyze the formation of glucose-6-P from glucose-1-P, although at a 1400-fold lower rate. 

Sequence Annotation

 ACT_SITE 102 102 Phosphoserine intermediate.
 METAL 102 102 Magnesium; via phosphate group (By
 METAL 241 241 Magnesium (By similarity).
 METAL 243 243 Magnesium (By similarity).
 METAL 245 245 Magnesium (By similarity).
 MOD_RES 102 102 Phosphoserine; by autocatalysis.  

Keyword

 Complete proteome; Direct protein sequencing; Isomerase; Magnesium; Metal-binding; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 445 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0008966; F:phosphoglucosamine mutase activity; IDA:EcoCyc.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
 GO:0046777; P:protein autophosphorylation; IDA:EcoCyc.
 GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; IMP:EcoCyc. 

Interpro

 IPR005844; A-D-PHexomutase_a/b/a-I.
 IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
 IPR005845; A-D-PHexomutase_a/b/a-II.
 IPR005846; A-D-PHexomutase_a/b/a-III.
 IPR005843; A-D-PHexomutase_C.
 IPR016066; A-D-PHexomutase_CS.
 IPR005841; Alpha-D-phosphohexomutase_SF.
 IPR006352; GlmM. 

Pfam

 PF02878; PGM_PMM_I
 PF02879; PGM_PMM_II
 PF02880; PGM_PMM_III
 PF00408; PGM_PMM_IV 

SMART

  

PROSITE

 PS00710; PGM_PMM 

PRINTS

 PR00509; PGMPMM.