CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032838
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Disrupted in schizophrenia 1 isoform 47 
Protein Synonyms/Alias
 Disrupted in schizophrenia 1 isoform 48; Disrupted in schizophrenia 1 isoform 53; Uncharacterized protein 
Gene Name
 DISC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
4****MSNKEGSGGFRubiquitination[1, 2]
27HNQRREGKDVNSSSPacetylation[2, 3]
40SPVMLAFKSFQQELDubiquitination[4]
68RDITVESKRTIFLLHacetylation[5]
68RDITVESKRTIFLLHubiquitination[1, 2, 4]
93ILTESEIKLDGVRQKacetylation[3]
93ILTESEIKLDGVRQKubiquitination[6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 138 AA 
Protein Sequence
MSNKEGSGGF RKRKHDNFPH NQRREGKDVN SSSPVMLAFK SFQQELDARH DKYERLVKLS 60
RDITVESKRT IFLLHRITSA PDMEDILTES EIKLDGVRQK IFQVAQELSG EDMHQFHRAI 120
TTEVYRQDPT HRGSWDQG 138 
Gene Ontology
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. 
Interpro
 IPR002848; Translin.
 IPR016068; Translin_N. 
Pfam
 PF01997; Translin 
SMART
  
PROSITE
  
PRINTS