CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029520
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Integrin beta 
Protein Synonyms/Alias
  
Gene Name
 ITGB2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
96EDHNGGQKQLSPQKVubiquitination[1]
137LRNPCPNKEKECQPPubiquitination[1]
139NPCPNKEKECQPPFAubiquitination[1]
237HLEDNLYKRSNEFDYubiquitination[1]
275RMVKTYEKLTEIIPKubiquitination[1]
305LIKNAYNKLSSRVFLubiquitination[1]
322NALPDTLKVTYDSFCubiquitination[1]
405DRSLCHGKGFLECGIubiquitination[1]
422CDTGYIGKNCECQTQubiquitination[1]
504RGLCFCGKCRCHPGFubiquitination[1]
576ISCAECLKFEKGPFGubiquitination[1]
579AECLKFEKGPFGKNCubiquitination[1]
601QLSNNPVKGRTCKERubiquitination[1, 2]
687RFEKEKLKSQWNNDNubiquitination[1, 2, 3, 4]
698NNDNPLFKSATTTVMubiquitination[1, 2]
708TTTVMNPKFAES***ubiquitination[1, 2, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Cell adhesion; Complete proteome; Integrin; Membrane; Reference proteome; Transmembrane. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 712 AA 
Protein Sequence
MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN FTGPGDPDSI 60
RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP QKVTLYLRPG FGSFVDKTVL 120
PFVNTHPDKL RNPCPNKEKE CQPPFAFRHV LKLTNNSNQF QTEVGKQLIS GNLDAPEGGL 180
DAMMQVAACP EEIGWRNVTR LLVFATDDGF HFAGDGKLGA ILTPNDGRCH LEDNLYKRSN 240
EFDYPSVGQL AHKLAENNIQ PIFAVTSRMV KTYEKLTEII PKSAVGELSE DSSNVVQLIK 300
NAYNKLSSRV FLDHNALPDT LKVTYDSFCS NGVTHRNQPR GDCDGVQINV PITFQVKVTA 360
TECIQEQSFV IRALGFTDIV TVQVLPQCEC RCRDQSRDRS LCHGKGFLEC GICRCDTGYI 420
GKNCECQTQG RSSQELEGSC RKDNNSIICS GLGDCVCGQC LCHTSDVPGK LIYGQYCECD 480
TINCERYNGQ VCGGPGRGLC FCGKCRCHPG FEGSACQCER TTEGCLNPRR VECSGRGRCR 540
CNVCECHSGY QLPLCQECPG CPSPCGKYIS CAECLKFEKG PFGKNCSAAC PGLQLSNNPV 600
KGRTCKERDS EGCWVAYTLE QQDGMDRYLI YVDESRECVA GPNIAAIVGG TVAGIVLIGI 660
LLLVIWKALI HLSDLREYRR FEKEKLKSQW NNDNPLFKSA TTTVMNPKFA ES 712 
Gene Ontology
 GO:0008305; C:integrin complex; IEA:InterPro.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:InterPro. 
Interpro
 IPR015812; Integrin_bsu.
 IPR015439; Integrin_bsu-2.
 IPR014836; Integrin_bsu_cyt_dom.
 IPR002369; Integrin_bsu_N.
 IPR012896; Integrin_bsu_tail.
 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR002035; VWF_A. 
Pfam
 PF08725; Integrin_b_cyt
 PF07965; Integrin_B_tail
 PF00362; Integrin_beta 
SMART
 SM00187; INB
 SM00423; PSI 
PROSITE
 PS00243; INTEGRIN_BETA 
PRINTS
 PR01186; INTEGRINB.