CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006693
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GMP reductase 1 
Protein Synonyms/Alias
 Guanosine 5'-monophosphate oxidoreductase 1; Guanosine monophosphate reductase 1 
Gene Name
 GMPR 
Gene Synonyms/Alias
 GMPR1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
13ADLKLDFKDVLLRPKacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. 
Sequence Annotation
 NP_BIND 108 131 NADP (By similarity).
 ACT_SITE 186 186 Thioimidate intermediate (By similarity).
 METAL 181 181 Potassium; via carbonyl oxygen (By
 METAL 183 183 Potassium; via carbonyl oxygen (By
 BINDING 219 219 NADP (By similarity).  
Keyword
 3D-structure; Complete proteome; Metal-binding; NADP; Oxidoreductase; Polymorphism; Potassium; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 345 AA 
Protein Sequence
MPRIDADLKL DFKDVLLRPK RSSLKSRAEV DLERTFTFRN SKQTYSGIPI IVANMDTVGT 60
FEMAAVMSQH SMFTAIHKHY SLDDWKLFAT NHPECLQNVA VSSGSGQNDL EKMTSILEAV 120
PQVKFICLDV ANGYSEHFVE FVKLVRAKFP EHTIMAGNVV TGEMVEELIL SGADIIKVGV 180
GPGSVCTTRT KTGVGYPQLS AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM 240
LGGMFSGHTE CAGEVFERNG RKLKLFYGMS SDTAMNKHAG GVAEYRASEG KTVEVPYKGD 300
VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFS 345 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0003920; F:GMP reductase activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0009117; P:nucleotide metabolic process; IEA:InterPro.
 GO:0006144; P:purine nucleobase metabolic process; TAS:Reactome.
 GO:0043101; P:purine-containing compound salvage; TAS:Reactome.
 GO:0009409; P:response to cold; TAS:ProtInc. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR005993; GMP_reduct1.
 IPR015875; IMP_DH/GMP_Rdtase_CS.
 IPR001093; IMP_DH_GMPRt. 
Pfam
 PF00478; IMPDH 
SMART
  
PROSITE
 PS00487; IMP_DH_GMP_RED 
PRINTS