CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022873
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 212 
Protein Synonyms/Alias
 Zinc finger protein C2H2-150 
Gene Name
 ZNF212 
Gene Synonyms/Alias
 ZNFC150 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
81KKLADCEKMAVEFGNubiquitination[1]
307QECGQGLKLKKDTSRubiquitination[1]
328CEITFRYKQQLATHLubiquitination[1]
462YSCTECEKSFVQKQHubiquitination[1]
467CEKSFVQKQHLLQHQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 141 219 KRAB.
 ZN_FING 316 338 C2H2-type 1.
 ZN_FING 369 391 C2H2-type 2.
 ZN_FING 427 449 C2H2-type 3.
 ZN_FING 455 477 C2H2-type 4.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 495 AA 
Protein Sequence
MAESAPARHR RKRRSTPLTS STLPSQATEK SSYFQTTEIS LWTVVAAIQA VEKKMESQAA 60
RLQSLEGRTG TAEKKLADCE KMAVEFGNQL EGKWAVLGTL LQEYGLLQRR LENVENLLRN 120
RNFWILRLPP GSKGEAPKVS RSLENDGVCF TEQEWENLED WQKELYRNVM ESNYETLVSL 180
KVLGQTEGEA ELGTEMLGDL EEEGPGGAHP AGGVMIKQEL QYTQEGPADL PGEFSCIAEE 240
QAFLSPEQTE LWGGQGSSVL LETGPGDSTL EEPVGSRVPS SSRTVGCPKQ KSHRQVQLDQ 300
ECGQGLKLKK DTSRPYECSE CEITFRYKQQ LATHLRSHSG WGSCTPEEPE ESLRPRPRLK 360
PQTKKAKLHQ CDVCLRSFSC KVSLVTHQRC HLQEGPSAGQ HVQERFSPNS LVALPGHIPW 420
RKSRSSLICG YCGKSFSHPS DLVRHQRIHT GERPYSCTEC EKSFVQKQHL LQHQKIHQRE 480
RGGLALEPGR PNGLL 495 
Gene Ontology
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0003677; F:DNA binding; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; NAS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR022137; DUF3669_Znf.
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF12417; DUF3669
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS