UniProt Accession

 RHO3_YEAST; Q00245; D6VVG9 

Genbank Protein ID

 D10006; Z46833; AY557857; BK006942 

Genbank Nucleotide ID

 BAA00897.1; CAA86874.1; AAS56183.1; DAA08435.1 

Protein Name

 GTP-binding protein RHO3 

Protein Synonyms/Alias

  

Gene Name

 RHO3 

Gene Synonyms/Alias

 YIL118W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
109	SLENVQNKWVGEITD	ubiquitination	[1]
181	EEGLAMAKKIGALRY	ubiquitination	[1]
194	RYLECSAKLNKGVNE	ubiquitination	[1]
197	ECSAKLNKGVNEAFT	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Plays an important role in cell growth. Required to keep the uninucleated state. May be involved in the organization of the cytoskeleton which affects microtubule functions. Most likely RHO3 and RHO4 of S.cerevisiae regulate partially overlapping but different pathways. 

Sequence Annotation

 NP_BIND 23 30 GTP (By similarity).
 NP_BIND 70 74 GTP (By similarity).
 NP_BIND 128 131 GTP (By similarity).
 MOTIF 45 53 Effector region (By similarity).
 MOD_RES 228 228 Cysteine methyl ester (By similarity).
 LIPID 228 228 S-farnesyl cysteine (By similarity).  

Keyword

 Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 231 AA 

Protein Sequence

Gene Ontology

 GO:0005933; C:cellular bud; IDA:SGD.
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0005525; F:GTP binding; IDA:SGD.
 GO:0003924; F:GTPase activity; IDA:SGD.
 GO:0030950; P:establishment or maintenance of actin cytoskeleton polarity; IMP:SGD.
 GO:0045921; P:positive regulation of exocytosis; IMP:SGD.
 GO:0090338; P:positive regulation of formin-nucleated actin cable assembly; IMP:SGD.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 

Pfam

 PF00071; Ras 

SMART

 SM00174; RHO 

PROSITE

 PS51420; RHO 

PRINTS

 PR00449; RASTRNSFRMNG.