UniProt Accession

 THNS1_HUMAN; Q8IYQ7; B3KWL1; D3DRV3; Q5VV21 

Genbank Protein ID

 AK125249; AL512598; CH471072; CH471072; BC035132 

Genbank Nucleotide ID

 BAG54173.1; CAH70791.1; EAW86113.1; EAW86114.1; AAH35132.1 

Protein Name

 Threonine synthase-like 1 

Protein Synonyms/Alias

 TSH1 

Gene Name

 THNSL1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
281	KLSCGEWKSLVGATY	acetylation	[1, 2, 3]
281	KLSCGEWKSLVGATY	ubiquitination	[4]
417	NGVSDFQKAQIIGSQ	ubiquitination	[4]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 MOD_RES 281 281 N6-acetyllysine.
 MOD_RES 351 351 N6-(pyridoxal phosphate)lysine (By  

Keyword

 Acetylation; Complete proteome; Polymorphism; Pyridoxal phosphate; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 743 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR027417; P-loop_NTPase.
 IPR000623; Shikimate_kinase/TSH1.
 IPR004450; Thr_synthase_like.
 IPR001926; Trp_syn_b_sub_like_PLP_eny_SF.
 IPR027456; TSH1_metazoan. 

Pfam

 PF00291; PALP
 PF01202; SKI 

SMART

  

PROSITE

  

PRINTS

 PR01100; SHIKIMTKNASE.