UniProt Accession

 RV167_YEAST; P39743; D6VT22 

Genbank Protein ID

 M92092; U32274; BK006938 

Genbank Nucleotide ID

 AAA35051.1; AAB64830.1; DAA12232.1 

Protein Name

 Reduced viability upon starvation protein 167 

Protein Synonyms/Alias

  

Gene Name

 RVS167 

Gene Synonyms/Alias

 YDR388W; D9509.8 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
22	QSFRQKFKMGEQTED	ubiquitination	[1]
242	YNRLQDMKIPYFDLN	ubiquitination	[1, 2]
481	GNYVQLNKN******	ubiquitination	[1, 2, 3, 4, 5]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [3] A proteomics approach to understanding protein ubiquitination.
 Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D, Marsischky G, Roelofs J, Finley D, Gygi SP.
 Nat Biotechnol. 2003 Aug;21(8):921-6. [PMID: 12872131]
 [4] Computational identification of ubiquitylation sites from protein sequences.
 Tung CW, Ho SY.
 BMC Bioinformatics. 2008 Jul 15;9:310. [PMID: 18625080]
 [5] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 

Functional Description

 Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Could be implicated in cytoskeletal reorganization in response to environmental stresses and could act in the budding site selection mechanism. 

Sequence Annotation

 DOMAIN 17 254 BAR.
 DOMAIN 421 482 SH3.
 MOD_RES 299 299 Phosphoserine; by FUS3 and PHO85.
 MOD_RES 321 321 Phosphoserine; by FUS3 and PHO85.
 MOD_RES 379 379 Phosphoserine; by FUS3 and PHO85.
 CROSSLNK 481 481 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Actin-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Isopeptide bond; Phosphoprotein; Reference proteome; SH3 domain; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 482 AA 

Protein Sequence

Gene Ontology

 GO:0030479; C:actin cortical patch; IDA:SGD.
 GO:0043332; C:mating projection tip; IDA:SGD.
 GO:0008092; F:cytoskeletal protein binding; ISS:SGD.
 GO:0051666; P:actin cortical patch localization; IMP:SGD.
 GO:0006897; P:endocytosis; IMP:SGD.
 GO:0060988; P:lipid tube assembly; IDA:SGD. 

Interpro

 IPR027267; AH/BAR-dom.
 IPR004148; BAR_dom.
 IPR001452; SH3_domain. 

Pfam

 PF03114; BAR
 PF00018; SH3_1 

SMART

 SM00721; BAR
 SM00326; SH3 

PROSITE

 PS51021; BAR
 PS50002; SH3 

PRINTS

 PR00452; SH3DOMAIN.