UniProt Accession

 PFD1_HUMAN; O60925; B2RD02; Q53F95; Q96EX6 

Genbank Protein ID

 Y17392; AK223394; AK315353; CH471062; BC003620; BC006202; BC011869 

Genbank Nucleotide ID

 CAA76759.1; BAD97114.1; BAG37749.1; EAW62071.1; AAH03620.1; AAH06202.1; AAH11869.1 

Protein Name

 Prefoldin subunit 1 

Protein Synonyms/Alias

  

Gene Name

 PFDN1 

Gene Synonyms/Alias

 PFD1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	APVDLELKKAFTELQ	ubiquitination	[1, 2]
11	PVDLELKKAFTELQA	ubiquitination	[2]
19	AFTELQAKVIDTQQK	ubiquitination	[3]
28	IDTQQKVKLADIQIE	ubiquitination	[2]
106	SYLERSVKEAEDNIR	ubiquitination	[2, 4]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; Chaperone; Complete proteome; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 122 AA 

Protein Sequence

Gene Ontology

 GO:0016272; C:prefoldin complex; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0051084; P:'de novo' posttranslational protein folding; TAS:Reactome.
 GO:0030036; P:actin cytoskeleton organization; IEA:Compara.
 GO:0042113; P:B cell activation; IEA:Compara.
 GO:0007049; P:cell cycle; TAS:ProtInc.
 GO:0021549; P:cerebellum development; IEA:Compara.
 GO:0021537; P:telencephalon development; IEA:Compara. 

Interpro

 IPR002777; PFD_beta-like.
 IPR009053; Prefoldin. 

Pfam

 PF01920; Prefoldin_2 

SMART

  

PROSITE

  

PRINTS