UniProt Accession

 METK1_RAT; P13444; Q5FVU2 

Genbank Protein ID

 X15734; X60822; BC089770 

Genbank Nucleotide ID

 CAA33754.1; AAH89770.1 

Protein Name

 S-adenosylmethionine synthase isoform type-1 

Protein Synonyms/Alias

 AdoMet synthase 1; Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/III 

Gene Name

 Mat1a 

Gene Synonyms/Alias

 Ams1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
89	RVVRDTIKHIGYDDS	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the formation of S-adenosylmethionine from methionine and ATP. 

Sequence Annotation

 NP_BIND 132 137 ATP (Potential).
 METAL 32 32 Magnesium (By similarity).
 METAL 58 58 Potassium (By similarity).
 METAL 284 284 Potassium (By similarity).
 METAL 292 292 Magnesium (By similarity).
 BINDING 30 30 Substrate (By similarity).
 BINDING 160 160 ATP (Potential).
 BINDING 180 180 Substrate (By similarity).
 BINDING 248 248 Substrate (By similarity).
 BINDING 250 250 Substrate; via carbonyl oxygen (By
 BINDING 259 259 Substrate (By similarity).
 MOD_RES 121 121 S-nitrosocysteine.
 DISULFID 35 61  

Keyword

 3D-structure; ATP-binding; Cobalt; Complete proteome; Disulfide bond; Magnesium; Metal-binding; Nucleotide-binding; One-carbon metabolism; Potassium; Reference proteome; S-nitrosylation; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 397 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0016363; C:nuclear matrix; IDA:RGD.
 GO:0043531; F:ADP binding; IDA:RGD.
 GO:0016597; F:amino acid binding; IDA:RGD.
 GO:0005524; F:ATP binding; IDA:RGD.
 GO:0000287; F:magnesium ion binding; IDA:RGD.
 GO:0004478; F:methionine adenosyltransferase activity; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
 GO:0051289; P:protein homotetramerization; IDA:RGD.
 GO:0006556; P:S-adenosylmethionine biosynthetic process; IDA:RGD. 

Interpro

 IPR022631; ADOMET_SYNTHASE_CS.
 IPR022630; S-AdoMet_synt_C.
 IPR022629; S-AdoMet_synt_central.
 IPR022628; S-AdoMet_synt_N.
 IPR002133; S-AdoMet_synthetase.
 IPR022636; S-AdoMet_synthetase_sfam. 

Pfam

 PF02773; S-AdoMet_synt_C
 PF02772; S-AdoMet_synt_M
 PF00438; S-AdoMet_synt_N 

SMART

  

PROSITE

 PS00376; ADOMET_SYNTHASE_1
 PS00377; ADOMET_SYNTHASE_2 

PRINTS