CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008218
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Caveolin-1 
Protein Synonyms/Alias
  
Gene Name
 Cav1 
Gene Synonyms/Alias
 Cav 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
8MADEVTEKQVYDAHTubiquitination[1]
16QVYDAHTKEIDLVNRubiquitination[1]
26DLVNRDPKHLNDDVVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G- protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. 
Sequence Annotation
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 5 5 N6-acetyllysine (By similarity).
 MOD_RES 6 6 Phosphotyrosine (By similarity).
 MOD_RES 14 14 Phosphotyrosine; by ABL1 and INSR.
 MOD_RES 25 25 Phosphotyrosine (By similarity).
 MOD_RES 42 42 Phosphotyrosine (By similarity).
 LIPID 133 133 S-palmitoyl cysteine (By similarity).
 LIPID 143 143 S-palmitoyl cysteine (By similarity).
 LIPID 156 156 S-palmitoyl cysteine (By similarity).  
Keyword
 Acetylation; Alternative initiation; Cell membrane; Complete proteome; Direct protein sequencing; Golgi apparatus; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 178 AA 
Protein Sequence
MADEVTEKQV YDAHTKEIDL VNRDPKHLND DVVKIDFEDV IAEPEGTHSF DGIWKASFTT 60
FTVTKYWFYR LLSTIFGIPM ALIWGIYFAI LSFLHIWAVV PCIKSFLIEI QCISRVYSIY 120
VHTFCDPLFE AIGKIFSNIR ISTQKEI 147 
Gene Ontology
 GO:0002080; C:acrosomal membrane; IDA:MGI.
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0005901; C:caveola; ISS:UniProtKB.
 GO:0005938; C:cell cortex; IDA:MGI.
 GO:0005929; C:cilium; IDA:MGI.
 GO:0005783; C:endoplasmic reticulum; ISS:HGNC.
 GO:0005768; C:endosome; ISS:UniProtKB.
 GO:0000139; C:Golgi membrane; ISS:HGNC.
 GO:0005887; C:integral to plasma membrane; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
 GO:0043234; C:protein complex; IPI:MGI.
 GO:0016504; F:peptidase activator activity; IMP:MGI.
 GO:0005198; F:structural molecule activity; IEA:Compara.
 GO:0001525; P:angiogenesis; IGI:MGI.
 GO:0097190; P:apoptotic signaling pathway; IEA:Compara.
 GO:0006816; P:calcium ion transport; IMP:MGI.
 GO:0070836; P:caveola assembly; IMP:MGI.
 GO:0072584; P:caveolin-mediated endocytosis; IEA:Compara.
 GO:0006874; P:cellular calcium ion homeostasis; IMP:MGI.
 GO:0071455; P:cellular response to hyperoxia; IEA:Compara.
 GO:0009267; P:cellular response to starvation; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IMP:MGI.
 GO:0051480; P:cytosolic calcium ion homeostasis; IEA:Compara.
 GO:0006897; P:endocytosis; TAS:MGI.
 GO:0000188; P:inactivation of MAPK activity; IMP:MGI.
 GO:0007595; P:lactation; IMP:MGI.
 GO:0019915; P:lipid storage; IMP:MGI.
 GO:0060056; P:mammary gland involution; IMP:MGI.
 GO:0000165; P:MAPK cascade; IMP:MGI.
 GO:0051899; P:membrane depolarization; IMP:MGI.
 GO:2000811; P:negative regulation of anoikis; IMP:UniProtKB.
 GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Compara.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IDA:UniProtKB.
 GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IMP:MGI.
 GO:0001937; P:negative regulation of endothelial cell proliferation; IMP:MGI.
 GO:0030857; P:negative regulation of epithelial cell differentiation; IMP:MGI.
 GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IMP:MGI.
 GO:0051001; P:negative regulation of nitric-oxide synthase activity; IMP:MGI.
 GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0032091; P:negative regulation of protein binding; IEA:Compara.
 GO:0031397; P:negative regulation of protein ubiquitination; IMP:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0042524; P:negative regulation of tyrosine phosphorylation of Stat5 protein; IDA:MGI.
 GO:0033484; P:nitric oxide homeostasis; IMP:MGI.
 GO:0010524; P:positive regulation of calcium ion transport into cytosol; IDA:BHF-UCL.
 GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Compara.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Compara.
 GO:0048554; P:positive regulation of metalloenzyme activity; IMP:MGI.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0045907; P:positive regulation of vasoconstriction; IMP:MGI.
 GO:0051260; P:protein homooligomerization; IDA:MGI.
 GO:0008104; P:protein localization; IMP:MGI.
 GO:2000286; P:receptor internalization involved in canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0030193; P:regulation of blood coagulation; IEA:Compara.
 GO:0019217; P:regulation of fatty acid metabolic process; IMP:MGI.
 GO:0006940; P:regulation of smooth muscle contraction; IMP:MGI.
 GO:0003057; P:regulation of the force of heart contraction by chemical signal; IGI:MGI.
 GO:0051592; P:response to calcium ion; IDA:BHF-UCL.
 GO:0043627; P:response to estrogen stimulus; IDA:MGI.
 GO:0001666; P:response to hypoxia; IMP:MGI.
 GO:0002931; P:response to ischemia; IMP:MGI.
 GO:0032570; P:response to progesterone stimulus; ISO:MGI.
 GO:0007519; P:skeletal muscle tissue development; IMP:MGI.
 GO:0031295; P:T cell costimulation; ISS:UniProtKB.
 GO:0006641; P:triglyceride metabolic process; IMP:MGI.
 GO:0001570; P:vasculogenesis; IMP:MGI.
 GO:0042310; P:vasoconstriction; IMP:MGI.
 GO:0016050; P:vesicle organization; IEA:Compara. 
Interpro
 IPR001612; Caveolin.
 IPR015504; Caveolin_1.
 IPR018361; Caveolin_CS. 
Pfam
 PF01146; Caveolin 
SMART
  
PROSITE
 PS01210; CAVEOLIN 
PRINTS