| Tag | Content |
|---|
| CPLM ID | CPLM-001440 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Legumain |
Protein Synonyms/Alias | Asparaginyl endopeptidase; Protease, cysteine 1 |
Gene Name | Lgmn |
Gene Synonyms/Alias | Prsc1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 179 | IRYMYEHKMYQKMVF | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity). |
Sequence Annotation | ACT_SITE 150 150 Potential.
ACT_SITE 191 191 Potential.
CARBOHYD 93 93 N-linked (GlcNAc...) (Potential).
CARBOHYD 169 169 N-linked (GlcNAc...) (Potential).
CARBOHYD 265 265 N-linked (GlcNAc...) (Potential).
CARBOHYD 274 274 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Glycoprotein; Hydrolase; Lysosome; Protease; Reference proteome; Signal; Thiol protease; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 435 AA |
Protein Sequence | MTWRVAVLLS LVLGAGAVPV GVDDPEDGGK HWVVIVAGSN GWYNYRHQAD ACHAYQIIHR 60
NGIPDEQIIV MMYDDIANSE ENPTPGVVIN RPNGTDVYKG VLKDYTGEDV TPENFLAVLR 120
GDAEAVKGKG SGKVLKSGPR DHVFIYFTDH GATGILVFPN DDLHVKDLNK TIRYMYEHKM 180
YQKMVFYIEA CESGSMMNHL PDDINVYATT AANPKESSYA CYYDEERGTY LGDWYSVNWM 240
EDSDVEDLTK ETLHKQYHLV KSHTNTSHVM QYGNKSISTM KVMQFQGMKH RASSPISLPP 300
VTHLDLTPSP DVPLTILKRK LLRTNDVKES QNLIGQIQQF LDARHVIEKS VHKIVSLLAG 360
FGETAERHLS ERTMLTAHDC YQEAVTHFRT HCFNWHSVTY EHALRYLYVL ANLCEAPYPI 420
DRIEMAMDKV CLSHY 435 |
Gene Ontology | GO:0045177; C:apical part of cell; IDA:MGI. GO:0005770; C:late endosome; IDA:MGI. GO:0005764; C:lysosome; IEA:UniProtKB-SubCell. GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro. GO:0008233; F:peptidase activity; IMP:MGI. GO:0040015; P:negative regulation of multicellular organism growth; IMP:MGI. GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara. GO:0006508; P:proteolysis; IDA:MGI. GO:0001101; P:response to acid; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |