CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026865
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 
Protein Synonyms/Alias
 Etfdh protein 
Gene Name
 Etfdh 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
35QLAAEQGKDIRVCLVacetylation[1, 2, 3]
64CLDPAAFKELFPDWKacetylation[2, 3]
71KELFPDWKEKGAPLNacetylation[2, 3, 4, 5]
71KELFPDWKEKGAPLNsuccinylation[5]
73LFPDWKEKGAPLNTPacetylation[3]
92RFAILTEKHRIPVPIacetylation[3]
162TNDVGIQKDGAPKTTacetylation[1, 2, 3]
162TNDVGIQKDGAPKTTubiquitination[6]
223ELWIIDEKKWKPGRVacetylation[1, 2, 3]
223ELWIIDEKKWKPGRVubiquitination[6]
296QPTLEGGKRIAYGARacetylation[2, 3]
355LAAESIFKQLTSENLacetylation[2, 3]
365TSENLQSKTTGLHVTubiquitination[6]
385LKQSWVWKELHAVRNacetylation[2]
436GSDSDQLKPAKDCTPacetylation[3]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [6] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 556 AA 
Protein Sequence
MERFAEEADV VIVGAGPAGL SAAIRLKQLA AEQGKDIRVC LVEKAAQIGA HTLSGACLDP 60
AAFKELFPDW KEKGAPLNTP VTEDRFAILT EKHRIPVPIL PGLPMNNHGN YIVRLGHLVS 120
WMGEQAEALG VEVYPGYAAA EVLYHEDGSV KGIATNDVGI QKDGAPKTTF ERGLELHAKV 180
TVFAEGCHGH LAKQLYKKFD LRASCDAQTY GIGLKELWII DEKKWKPGRV DHTVGWPLDR 240
HTYGGSFLYH LNEGEPLVAV GFVVGLDYQN PYLSPFREFQ RWKHHPSIQP TLEGGKRIAY 300
GARALNEGGL QSIPKLTFPG GLLIGCSPGF MNVPKIKGTH TAMKSGSLAA ESIFKQLTSE 360
NLQSKTTGLH VTEYEDNLKQ SWVWKELHAV RNIRPSCHGI LGVYGGMIYT GIFYWILRGM 420
EPWTLKHKGS DSDQLKPAKD CTPIEYPKPD GQISFDLLSS VALSGTNHEH DQPAHLTLKD 480
DSIPVNRNLS IYDGPEQRFC PAGVYEFVPL EQGDGFRLQI NAQNCVHCKT CDIKDPSQNI 540
NWVVPEGGGG PAYNGM 556 
Gene Ontology
 GO:0031305; C:integral to mitochondrial inner membrane; IEA:Compara.
 GO:0017133; C:mitochondrial electron transfer flavoprotein complex; TAS:MGI.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:Compara.
 GO:0009055; F:electron carrier activity; IEA:Compara.
 GO:0004174; F:electron-transferring-flavoprotein dehydrogenase activity; IEA:Compara.
 GO:0048039; F:ubiquinone binding; IEA:Compara.
 GO:0022900; P:electron transport chain; IEA:Compara.
 GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IEA:Compara. 
Interpro
 IPR017896; 4Fe4S_Fe-S-bd.
 IPR007859; ETFD_OxRdtase.
 IPR000103; Pyridine_nuc-diS_OxRdtase_2. 
Pfam
 PF05187; ETF_QO 
SMART
  
PROSITE
 PS51379; 4FE4S_FER_2 
PRINTS
 PR00469; PNDRDTASEII.