| Tag | Content |
|---|
| CPLM ID | CPLM-021719 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier family 40 member 1 |
Protein Synonyms/Alias | Ferroportin-1; Iron-regulated transporter 1; Metal transporter protein 1; MTP1 |
Gene Name | Slc40a1 |
Gene Synonyms/Alias | Fpn1; Ireg1; Slc11a3; Slc39a1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 240 | LAVKAALKVEESELK | ubiquitination | [1] | | 247 | KVEESELKQLTSPKD | ubiquitination | [1] | | 269 | GTHLMGEKDSNIREL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). |
Sequence Annotation | CARBOHYD 166 166 N-linked (GlcNAc...) (Potential).
CARBOHYD 174 174 N-linked (GlcNAc...) (Potential).
CARBOHYD 437 437 N-linked (GlcNAc...) (Potential).
CARBOHYD 566 566 N-linked (GlcNAc...) (Potential). |
Keyword | Cell membrane; Complete proteome; Glycoprotein; Ion transport; Iron; Iron transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 570 AA |
Protein Sequence | MTKARDQTHQ EGCCGSLANY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL VELYGNSLLL 60
TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN VSVILCGIIL MMVFLHKNEL 120
LTMYHGWVLT VCYILIITIA NIANLASTAT AITIQRDWIV VVAGENRSRL ADMNATIRRI 180
DQLTNILAPM AVGQIMTFGS PVIGCGFISG WNLVSMCVEY FLLWKVYQKT PALAVKAALK 240
VEESELKQLT SPKDTEPKPL EGTHLMGEKD SNIRELECEQ EPTCASQMAE PFRTFRDGWV 300
SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSILMGASA ITGIMGTVAF 360
TWLRRKCGLV RTGLFSGLAQ LSCLILCVIS VFMPGSPLDL SVSPFEDIRS RFVNVEPVSP 420
TTKIPETVFT TEMHMSNMSN VHEMSTKPIP IVSVSLLFAG VIAARIGLWS FDLTVTQLLQ 480
ENVIESERGI INGVQNSMNY LLDLLHFIMV ILAPNPEAFG LLVLISVSFV AMGHLMYFRF 540
AQKTLGNQIF VCGPDEKEVT DENQPNTSVV 570 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005771; C:multivesicular body; IDA:MGI. GO:0005886; C:plasma membrane; IDA:MGI. GO:0008021; C:synaptic vesicle; IDA:MGI. GO:0005381; F:iron ion transmembrane transporter activity; IDA:MGI. GO:0006915; P:apoptotic process; IMP:MGI. GO:0006879; P:cellular iron ion homeostasis; IEA:Compara. GO:0003158; P:endothelium development; IMP:MGI. GO:0002260; P:lymphocyte homeostasis; IMP:MGI. GO:0060586; P:multicellular organismal iron ion homeostasis; IMP:MGI. GO:0060345; P:spleen trabecula formation; IMP:MGI. |
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