CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008349
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ETS-like protein pointed, isoform P2/D 
Protein Synonyms/Alias
 D-ETS-2 
Gene Name
 pnt 
Gene Synonyms/Alias
 ETS2; Ets58AB; CG17077 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
113LSSLVESKNIFIKEEacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
 Required for glial-neuronal cell interactions at the ventral midline which are necessary for the proper elaboration of commissures in the embryonic CNS. 
Sequence Annotation
 DOMAIN 164 250 PNT.
 DNA_BIND 610 690 ETS.  
Keyword
 Alternative splicing; Complete proteome; Developmental protein; DNA-binding; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 718 AA 
Protein Sequence
MELAICKTDL SATKFMLPPA LPSSAAIGSS SAVASTASHF LDKAAHELFQ LNAINGHLFK 60
SPASSHLNSV GSPSILSQLN GIGNSGNHSG QVSTMRLKKN RKVTFLSSLV ESKNIFIKEE 120
PIHGCKDLCS LSDISDHEAS LEVPTALPPL TPGTNRKVNE VLKASFASWE KEVQKCNITK 180
DPREWTEEHV IYWLNWAKNE FSLVSMNLDP FYKMKGRAMV DLGKEKFLAI TPPFTGDILW 240
EHLDILQKDC EKPNEDIVHG NSFESATTAS VCGSDHQVAN YPNETHANSN NSSINSRLSM 300
DYVTSAGNSD NKNFHRATPH SHNGYNTSNT HDRINNSTPP QQQQSQQPTV NGSGSASSNN 360
NNSMLPPAVQ QSNNENNNTS SSNTNNSSNN NNNSGGSNNS NAGSNNNNNN NNNINFMAAA 420
AIFQHHLKEE PGTQNGNIGG YGGGSNSQND PTDLSSYGLP AHLAAYGGGS GSGPTGGRSS 480
GGGGDESDYH STISAQDHQS QQSSGGNGSG GASGGSTGNS NGYLDSSSEF YGSYAGRNRF 540
HDGYPPEFTP YDAQSFQSMG PQPTAMDQWG AAHAHQHPAA YMSTLGLDKG LLGGYTTQGG 600
VPCFTGSGPI QLWQFLLELL LDKTCQSFIS WTGDGWEFKL TDPDEVARRW GIRKNKPKMN 660
YEKLSRGLRY YYDKNIIHKT AGKRYVYRFV CDLQNLVGHT PEELVAKYDL KIEKKDVD 718 
Gene Ontology
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:FlyBase.
 GO:0035225; P:determination of genital disc primordium; IMP:FlyBase.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; NAS:FlyBase.
 GO:0007427; P:epithelial cell migration, open tracheal system; IMP:FlyBase.
 GO:0061331; P:epithelial cell proliferation involved in Malpighian tubule morphogenesis; IMP:FlyBase.
 GO:0007455; P:eye-antennal disc morphogenesis; IMP:FlyBase.
 GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
 GO:0048747; P:muscle fiber development; IMP:FlyBase.
 GO:0043066; P:negative regulation of apoptotic process; IGI:FlyBase.
 GO:0009997; P:negative regulation of cardioblast cell fate specification; IMP:FlyBase.
 GO:0030707; P:ovarian follicle cell development; TAS:FlyBase.
 GO:0061320; P:pericardial nephrocyte differentiation; IMP:FlyBase.
 GO:0007422; P:peripheral nervous system development; TAS:FlyBase.
 GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.
 GO:0008284; P:positive regulation of cell proliferation; IMP:FlyBase.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:FlyBase.
 GO:0007428; P:primary branching, open tracheal system; IMP:FlyBase.
 GO:0007464; P:R3/R4 cell fate commitment; IMP:FlyBase.
 GO:0045467; P:R7 cell development; TAS:FlyBase.
 GO:0007265; P:Ras protein signal transduction; TAS:FlyBase.
 GO:0045610; P:regulation of hemocyte differentiation; IMP:FlyBase.
 GO:0050767; P:regulation of neurogenesis; IMP:FlyBase.
 GO:0007429; P:secondary branching, open tracheal system; IMP:FlyBase.
 GO:0007362; P:terminal region determination; IGI:FlyBase.
 GO:0008293; P:torso signaling pathway; IGI:FlyBase.
 GO:0060439; P:trachea morphogenesis; IMP:FlyBase.
 GO:0007426; P:tracheal outgrowth, open tracheal system; IMP:FlyBase.
 GO:0048190; P:wing disc dorsal/ventral pattern formation; IGI:FlyBase. 
Interpro
 IPR000418; Ets_dom.
 IPR003118; Pointed_dom.
 IPR013761; SAM/pointed.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00178; Ets
 PF02198; SAM_PNT 
SMART
 SM00413; ETS
 SM00251; SAM_PNT 
PROSITE
 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3
 PS51433; PNT 
PRINTS
 PR00454; ETSDOMAIN.