| Tag | Content |
|---|
| CPLM ID | CPLM-019959 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | WD repeat-containing protein 6 |
Protein Synonyms/Alias | mWDR6 |
Gene Name | Wdr6 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 237 | DRSVRLWKVGDLRVP | ubiquitination | [1] | | 432 | PTAAVEQKLFQGKVH | ubiquitination | [1] | | 490 | RYLLPPSKQRWHTCS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Enhances the STK11/LKB1-induced cell growth suppression activity (By similarity). Negative regulator of amino acid starvation-induced autophagy (By similarity). |
Sequence Annotation | REPEAT 70 109 WD 1.
REPEAT 114 151 WD 2.
REPEAT 155 197 WD 3.
REPEAT 207 246 WD 4.
REPEAT 256 294 WD 5.
REPEAT 295 335 WD 6.
REPEAT 346 384 WD 7.
REPEAT 433 475 WD 8.
REPEAT 489 528 WD 9.
REPEAT 567 605 WD 10.
REPEAT 611 650 WD 11.
REPEAT 652 692 WD 12.
REPEAT 725 765 WD 13.
REPEAT 767 798 WD 14.
REPEAT 860 905 WD 15.
REPEAT 912 958 WD 16.
REPEAT 982 1024 WD 17.
REPEAT 1047 1085 WD 18. |
Keyword | Cell cycle; Complete proteome; Cytoplasm; Reference proteome; Repeat; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1125 AA |
Protein Sequence | MDAFGDYVWP RATSELILLP VTGLECVGDR LLAGEGPDLL VYNLDLGGHL RMVKRVQNLL 60
GHFLIHGFRV RPEPKGDLDS EAMIAVFGSK GLKVVKVSWG QSHLRELWRS GLWNMSDWIW 120
DVRWIEGNVA VALGHNSVVL YDPVIGCMLQ DVPCTDRCTL SSACLVGDTW KELTIVAGAV 180
SNELLIWYPA TALTDNKPVA PDRRVSGHVG VIFSMSYLES KGLLATASED RSVRLWKVGD 240
LRVPGGRVQN IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHRGRG 300
IRAIATHERQ AWVVTGGDDS GIRLWHLAGR GYPGLGVSSL SFKSPSRPGA LKAVTLAGSW 360
RVLAVTDVGS LYLYDLEVKS WEQLLEDNRF RSYCLLEAAP GPEGFGLCAL ANGEGLVKVV 420
PINTPTAAVE QKLFQGKVHS LSWALRGYEE LLLLASGPGG VIACLEISAA PTGKAIFVKE 480
RCRYLLPPSK QRWHTCSAFL PPGDFLVCGD RRGSVMLFPV RPCLFKKPGA GSKAITAAEA 540
PGAGSGSGGS ESVPTGIGPV STLHSLHGKQ GVTSVTCHGG YLYSTGRDSS YFQLFVHGGH 600
LQPVLRQKAC RGMNWVAGLR MVPDGSMVIL GFHANEFVVW SPRSHEKLHI VNCGGGHRSW 660
AFSDTEAAMA FTYLKDGEVM LYRALGGCIR PNVILREGLH GREITCVKRV GTVTLGPEFE 720
VPNLEHPDSL EPGSEGPGLI DIVITGSEDT TVCVLALPTT TGSAHALTSV CNHISSVRAL 780
AVWAVGTPGG PQDTRPGLTA QVVSAGGRAE IHCFSVMVTP DASTPSRLAC HVMHLSSHRL 840
DEYWDRQRNK HKMIKVDPET RYMSLAICEL DNDRPGLGPG PLVAAACSDG AVRLFLLQDS 900
GRILHLLAES FHHKRCVLKV HSFTHEAPNQ RRRLILCSAA TDGSLAFWDL TTAMDKGSTT 960
LELPAHPGLP YQMGTPSMTV QAHSCGVNSL HTLPTPEGHH LVASGSEDGS LHVFTLAVKM 1020
PEPEEADGEA ELVPQLCVLE EYSVPCAHAA HVTGVKILSP KLMVSASIDQ RLTFWRLGQG 1080
EPTFMNSTVY HVPDVADMDC WPVSPEFGHR CALAGQGLEV YNWYD 1125 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0008180; C:signalosome; IEA:Compara. GO:0007050; P:cell cycle arrest; IEA:Compara. GO:0010507; P:negative regulation of autophagy; IEA:Compara. GO:0008285; P:negative regulation of cell proliferation; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |