CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030055
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine kinase 3 (STE20 homolog, yeast) 
Protein Synonyms/Alias
 Serine/threonine-protein kinase 24 
Gene Name
 Stk3 
Gene Synonyms/Alias
 rCG_60292 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
128DEIATILKSTLKGLEacetylation[1]
132TILKSTLKGLEYLHFacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 491 AA 
Protein Sequence
MEQPPAPKSK LKKLSEDSLT KQPEEVFDVL EKLGEGSYGS VFKAIHKESG QVVAIKQVPV 60
ESDLQEIIKE ISIMQQCDSP YVVKYYGSYF KNTDLWIVME YCGAGSVSDI IRLRNKTLTE 120
DEIATILKST LKGLEYLHFM RKIHRDIKAG NILLNTEGHA KLADFGVAGQ LTDTMAKRNT 180
VIGTPFWMAP EVIQEIGYNC VADIWSLGIT SIEMAEGKPP YADIHPMRAI FMIPTNPPPT 240
FRKPELWSDD FTDFVKKCLV KSPEQRATAT QLLQHPFIKN AKPVSILREL ITEGMEIKAK 300
RHEEQQRELE DEEENSDEDE LDSHTMVKTS SEGVGTMRAT STMSEGAQTM IEHNSTMLES 360
DLGTMVINSE DEEEEDGTMK RNATSPQVQR PSFMDYFDKQ DFKNKSHENC DQSMREPCPM 420
SNNVFPDNWR VPQDGDFDFL KNLSLEELQM RLKALDPMME REIEELHQRY SAKRQPILDA 480
MDAKKRRQQN F 491 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
 GO:0060706; P:cell differentiation involved in embryonic placenta development; IEA:Compara.
 GO:0007417; P:central nervous system development; IEA:Compara.
 GO:0003157; P:endocardium development; IEA:Compara.
 GO:0035329; P:hippo signaling cascade; IEA:Compara.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0046621; P:negative regulation of organ growth; IEA:Compara.
 GO:0001841; P:neural tube formation; IEA:Compara.
 GO:0046330; P:positive regulation of JNK cascade; IEA:Compara.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IEA:Compara.
 GO:0060215; P:primitive hemopoiesis; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR024205; Mst1_SARAH_domain.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR011524; SARAH_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom. 
Pfam
 PF11629; Mst1_SARAH
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS50951; SARAH 
PRINTS