UniProt Accession

 SCN2B_MOUSE; Q56A07 

Genbank Protein ID

 BC092225 

Genbank Nucleotide ID

 AAH92225.1 

Protein Name

 Sodium channel subunit beta-2 

Protein Synonyms/Alias

  

Gene Name

 Scn2b 

Gene Synonyms/Alias

 Gm183 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
197	KLSTDDLKTEEEGKM	ubiquitination	[1]
203	LKTEEEGKMDGEGNA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). 

Sequence Annotation

 DOMAIN 32 154 Ig-like C2-type.
 CARBOHYD 42 42 N-linked (GlcNAc...) (Potential).
 CARBOHYD 66 66 N-linked (GlcNAc...) (Potential).
 CARBOHYD 74 74 N-linked (GlcNAc...) (Potential).
 DISULFID 50 127 By similarity.
 DISULFID 55 55 Interchain; with alpha subunit (By  

Keyword

 Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Ion channel; Ion transport; Membrane; Reference proteome; Signal; Sodium; Sodium channel; Sodium transport; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 215 AA 

Protein Sequence

Gene Ontology

 GO:0001518; C:voltage-gated sodium channel complex; IEA:Compara.
 GO:0017080; F:sodium channel regulator activity; IEA:Compara.
 GO:0086006; F:voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential; IEA:Compara.
 GO:0060048; P:cardiac muscle contraction; IEA:Compara.
 GO:0007399; P:nervous system development; IEA:Compara.
 GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Compara.
 GO:0086002; P:regulation of cardiac muscle cell action potential involved in contraction; IEA:Compara.
 GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Compara.
 GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IEA:Compara.
 GO:0046684; P:response to pyrethroid; IEA:Compara. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set.
 IPR000920; Myelin_P0. 

Pfam

 PF07686; V-set 

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS

 PR00213; MYELINP0.