CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021106
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Modulator of apoptosis 1 
Protein Synonyms/Alias
 MAP-1 
Gene Name
 Moap1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
111CRLNEFLKGEGMTMGubiquitination[1]
255NPRALQVKYLTTYQKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (By similarity). 
Sequence Annotation
 REGION 120 127 BH3-like.
 REGION 204 207 RASSF1-binding (By similarity).  
Keyword
 Apoptosis; Complete proteome; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 352 AA 
Protein Sequence
MTLRLLEDWC RGMDMNPRKA LLVAGIPPTC GVADIEEALQ AGLAPLGEHR LLGRMFRRDE 60
NKNVALIGLT VETGSALVPK EIPAKGGVWR VIFKPPDTDS DFLCRLNEFL KGEGMTMGEL 120
TRVLGNRNDP LGLDPGIMIP EIRAPMLAQA LNEALKPTLQ YLRYKKLSVF SGRDPPGPGE 180
EEFESWMFHT SQVMKTWQVS DVEKRRRLIE SLRGPAFEII RVLKINNPFI TVAECLKTLE 240
TIFGIIDNPR ALQVKYLTTY QKTDEKLSAY VLRLEPLLQK LVQKGAIEKE VVNQARLDQV 300
IAGAVHKSVR RELGLPEGSP APGLLQLLTL IKDKEAEEEE VLLQAELEGY CT 352 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0030262; P:apoptotic nuclear changes; IEA:Compara. 
Interpro
 IPR026523; PNMA.
 IPR026528; PNMA1/MOAP1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS