UniProt Accession

 GEM_HUMAN; P55040; B2RA31 

Genbank Protein ID

 U10550; U13052; AK314017; CH471060; BC022010 

Genbank Nucleotide ID

 AAA64911.1; AAC50067.1; BAG36728.1; EAW91709.1; AAH22010.1 

Protein Name

 GTP-binding protein GEM 

Protein Synonyms/Alias

 GTP-binding mitogen-induced T-cell protein; RAS-like protein KIR 

Gene Name

 GEM 

Gene Synonyms/Alias

 KIR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
276	FWGKIVAKNNKNMAF	acetylation	[1]
279	KIVAKNNKNMAFKLK	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. 

Sequence Annotation

 NP_BIND 82 89 GTP (By similarity).
 NP_BIND 191 194 GTP (By similarity).
 REGION 266 285 Calmodulin-binding (By similarity).  

Keyword

 3D-structure; Calmodulin-binding; Cell membrane; Complete proteome; GTP-binding; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 296 AA 

Protein Sequence

Gene Ontology

 GO:0009898; C:internal side of plasma membrane; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0019003; F:GDP binding; IDA:BHF-UCL.
 GO:0005525; F:GTP binding; IDA:BHF-UCL.
 GO:0003924; F:GTPase activity; IDA:BHF-UCL.
 GO:0000287; F:magnesium ion binding; IDA:BHF-UCL.
 GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR017358; Small_GTPase_GEM/REM/Rad.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

  

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.