UniProt Accession

 CRLS1_HUMAN; Q9UJA2; D3DW09; E9PAT4; Q27RP0; Q69YQ5 

Genbank Protein ID

 DQ386730; AF241784; AL035461; CH471133; CH471133; AL832419 

Genbank Nucleotide ID

 ABD46888.1; AAG44472.1; CAB55278.1; EAX10401.1; EAX10402.1; CAH10649.1 

Protein Name

 Cardiolipin synthase 

Protein Synonyms/Alias

 CLS; Protein GCD10 homolog 

Gene Name

 CRLS1 

Gene Synonyms/Alias

 C20orf155; CLS1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
225	PTPRTLAKYFNPCYA	ubiquitination	[1, 2, 3]
294	SYYHYGRKTVQVIKD	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Lipid biosynthesis; Lipid metabolism; Membrane; Mitochondrion; Mitochondrion inner membrane; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 301 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
 GO:0032049; P:cardiolipin biosynthetic process; TAS:Reactome.
 GO:0036148; P:phosphatidylglycerol acyl-chain remodeling; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR000462; CDP-OH_P_trans. 

Pfam

 PF01066; CDP-OH_P_transf 

SMART

  

PROSITE

 PS00379; CDP_ALCOHOL_P_TRANSF 

PRINTS