CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006607
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SET domain-containing protein 3 
Protein Synonyms/Alias
  
Gene Name
 SET3 
Gene Synonyms/Alias
 YKR029C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
243SNNSIDSKNESASVNacetylation[1]
557ILHRLEEKAQNTIERubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Required for both gene activation and repression. Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis. Required for the transcriptional activation of genes with high activity. 
Sequence Annotation
 DOMAIN 313 456 SET.
 ZN_FING 117 166 PHD-type.
 MOD_RES 236 236 Phosphoserine.
 MOD_RES 684 684 Phosphoserine.
 MOD_RES 718 718 Phosphoserine.
 MOD_RES 719 719 Phosphothreonine.
 MOD_RES 741 741 Phosphoserine.  
Keyword
 Activator; Chromatin regulator; Complete proteome; Meiosis; Metal-binding; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 751 AA 
Protein Sequence
MSVPNSKEQS LLDDASTLLL FSKGKKRAEE ASKIGSKTDT IEHDESHERE KKGAIEMAAA 60
ALATASTVSL PLKKATEQSA AEAATSTAAK EETENQPQKQ PQWPVPDSYI VDPDAGIITC 120
ICDLNDDDGF TIQCDHCNRW QHAICYGIKD IGMAPDDYLC NSCDPREVDI NLARKIQQER 180
INVKTVEPSS SNNSASNKNN GRDRASSTTI SDVGDSFSTD QDNTNHRDKR RKRNPSNNSI 240
DSKNESASVN SSDGLTSMPK KKEHFLSAKD AYGAIYLPLK DNVFKSDLIE PFLNKHMDDN 300
WVIQYPHKTF KSVSIEVKPY ADIAYSRTYP GFTKLGVYLK KDCIKGDFIQ EILGELDFYK 360
NYLTDPRNHY RIWGTAKRRV IFHSHWPIYI DARLSGNSTR YLRRSCQPNV ELVTIKLQDT 420
DNRNDKSSGR KSSRIKFVLR ALRDISEDEE LYIKWQWDSK HPILKLIKGM TIDSLDDLER 480
YGLINSVETI LSNGECGCGN NSKDCYLLKV KRYAQSLYKS VKSRGKMNNR YKLNEILNQY 540
NCKKRREPPI LHRLEEKAQN TIERAPILLN NFYRQKFLNR NNGPKIPQKN TIDSTNNPDD 600
IAKPFKFALF AQHSSNISVP KKNETSEKPL IITKSTDYDE SHITNIEELP IPVLLPINKT 660
SRQTANDVEE SQSKNEHKLS RTPSLSNFNK ELSKEAQHSQ AKTKEIMTEA SVNSRRESTP 720
ESIMHLSDFS SSQLHSKKKL SFADYRKKLL K 751 
Gene Ontology
 GO:0070210; C:Rpd3L-Expanded complex; IDA:SGD.
 GO:0034967; C:Set3 complex; IDA:SGD.
 GO:0035064; F:methylated histone residue binding; IDA:SGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016575; P:histone deacetylation; IDA:SGD.
 GO:0007126; P:meiosis; IEA:UniProtKB-KW.
 GO:0045835; P:negative regulation of meiosis; IMP:SGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001214; SET_dom.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00628; PHD
 PF00856; SET 
SMART
 SM00249; PHD
 SM00317; SET 
PROSITE
 PS50280; SET
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS