| Tag | Content |
|---|
| CPLM ID | CPLM-000870 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Epithelial cell adhesion molecule |
Protein Synonyms/Alias | Ep-CAM; Epithelial glycoprotein 314; EGP314; Protein D5.7A; Tumor-associated calcium signal transducer 1; CD326 |
Gene Name | Epcam |
Gene Synonyms/Alias | Tacstd1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 179 | SRYMLNPKFIKSIMY | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). |
Sequence Annotation | DOMAIN 63 135 Thyroglobulin type-1.
CARBOHYD 111 111 N-linked (GlcNAc...) (Potential).
CARBOHYD 198 198 N-linked (GlcNAc...) (Potential).
DISULFID 27 46 By similarity.
DISULFID 29 59 By similarity.
DISULFID 38 48 By similarity.
DISULFID 66 99 By similarity.
DISULFID 110 116 By similarity.
DISULFID 118 135 By similarity. |
Keyword | Cell junction; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Reference proteome; Repeat; Signal; Tight junction; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 315 AA |
Protein Sequence | MAPPKALAFG LLLAVVTATL AAAQKDCVCN NYKLTSRCYE NENGECQCTS YGTQNTVICS 60
KLASKCLVMK AEMTHSKSGR RMKPEGAIQN NDGLYDPECD EQGLFKAKQC NGTATCWCVN 120
TAGVRRTDKD TEITCSERVR TYWIIIELKH KERAQPYNFE SLHTALQDTF ASRYMLNPKF 180
IKSIMYENNV ITIDLMQNSS QKTQDDVDIA DVAYYFEKDV KGESLFHSSK SMDLRVNGEL 240
LDLDPGQTLI YYVDEKAPEF SMQGLTAGII AVIVVVVLAV IAGIVVLVIS TRKRSAKYEK 300
AEIKEMGEIH RELNA 315 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:Compara. GO:0016323; C:basolateral plasma membrane; IEA:Compara. GO:0009986; C:cell surface; IEA:Compara. GO:0016021; C:integral to membrane; IDA:RGD. GO:0016328; C:lateral plasma membrane; IDA:UniProtKB. GO:0005923; C:tight junction; IDA:UniProtKB. GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB. GO:0001657; P:ureteric bud development; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |