CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038408
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Pi4ka 
Protein Synonyms/Alias
  
Gene Name
 Pi4ka 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
149SEESLLSKLFPKVSPubiquitination[1]
194VCQEGTLKRKTSSVSubiquitination[1]
549YISQESDKDAHLIPDubiquitination[1]
574VALRDTPKVMEPILQubiquitination[1]
780PLLTFPSKEPLRSVLubiquitination[1]
794LQYNSAMKNDTVTPAubiquitination[1]
1505VQLPARFKNTEAIGNubiquitination[1]
1691TNVSAIIKPYPKGDEubiquitination[1]
1701PKGDERKKACLSALSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2044 AA 
Protein Sequence
MCPVDFHGIF QLDERRRDAV IALGIFLIES DLQHKDCVVP YLLRLLRGLP KVYWVEESTA 60
RKGRGNLPVA ESFSFCLVTL LSDVACRDPS LRDEILEAIL QVLHVLLGMC QALEIQEKEY 120
LCKYAIPCLI GISRSFGRYS NSEESLLSKL FPKVSPHSLR IPEELEGVRR RSFNDFRSIL 180
PSNLLTVCQE GTLKRKTSSV SSISQVSPER GIPPPSSPGG SAFHYFEASC LPDGTALEPE 240
YYFSTISSSF SISPLFNGIT YKEFCIPLEM LRELLNLVKK IVEEPVLKSL DAIVAGVMEA 300
NPSADLYYTT FSDPLYLTMF KMLRDTLYYM KDLPTSFVKE IHDFVLEQFN MSQGELQKIL 360
HDADRIHSEM SPLKLRCQAN AACVDLMVWA VKDEQGAENL CIKLSEKLQS KTSSKVIIAH 420
LPLLICCLQG LGRLCERFPV VVHSVTPSLR DFLVIPSPVL VKLYKYHSQY HTVAGSDIKI 480
SVTNEHSEST LNVLPGKKNQ PSMYEQLRDI AIDNICRCLK AGLTVDPVIV EAFLASLSNR 540
LYISQESDKD AHLIPDHTIR ALGHIAVALR DTPKVMEPIL QILQQKFCQP PSPLDVLIID 600
QLGCLVITGN QYIYQEVWNL FQQISVKASS VVYSATKDYK DHGYRHCSLA VINALANIAA 660
NIQEEHLVDE LLMNLLELFV QLGLEGKRAS ERASEKGPAL KASSSAGNLG VLIPVIAVLT 720
RRLPPIKEAK PRLQKLFRDF WLYSVLMGFA VEGSGLWPEE WYEGVCEIAT KSPLLTFPSK 780
EPLRSVLQYN SAMKNDTVTP AELSELRSTI INLLDPPPEV SALINKLDFA MSTYLLSVYR 840
LEYMRVLRST DPDRFQVMFC YFEDKAIQKD KSGMMQCVIA VADKVFDAFL NMMAEKAKTK 900
ENEEELERHA QFLLVNFNHI HKRIRRVADK YLSGLVDKFP HLLWSGTVLK TMLDILQTLS 960
LSLSADIHKD QPYYDIPDAP YRITVPDTYE ARESIVKDFA ARCGMILQEA MKWAPTVTKS 1020
HLQEYLNKHQ NWVSGLSQHT GLAMATESIL HFAGYNKQNT TLGATQLTER PACVKKDYSN 1080
FMASLNLRNR YAGEVHGMIR FSGATGQMSD LNKMMVQDLI TALDHSHPQH YTQAMFKLTA 1140
MLISSKDCDP QLLHHLCWGP LRMFNEHGME TALACWEWLL AGKNGVEVPF MREMAGAWHM 1200
TVEQKFGLFS VETKEADPLA ASEASQPRPC PPEVTPHYIW IDFLVQRFEI AKYCSSDQVE 1260
IFSSLLQRSM SLNIGGARGS MNRHVAAIGP RFKLLTLGLS LLHADVVPNA TIRNVLREKI 1320
YSTAFDYFSC PPKFPTQGEK RLREDISIMI KFWTAMFSDK KYLTASQLVP PDNQDTRSNL 1380
DITVGSRQQA TQGWINTYPL SSGMSTISKK SGMSKKTNRG SQLHKYYMKR RTLLLSLLAT 1440
EIERLITWYN PLSAPELELD QAGENSVANW RSKYISLSEK QWKDNVNLAW SISPYLAVQL 1500
PARFKNTEAI GNEVTRLVRL DPGAVSDVPE AIKFLVTWHT IDADAPELSH VLCWAPTDPP 1560
TGLSYFSSMY PPHPLTAQYG VKVLRSFPPD AILFYIPQIV QALRYDKMGY VREYILWAAA 1620
KSQLLAHQFI WNMKTNIYLD EEGHQKDPDI GDLLEQLVEE ITGSLSGPAK DFYQREFDFF 1680
NKITNVSAII KPYPKGDERK KACLSALSEV KVQPGCYLPS NPEAIVLDID YKSGTPMQSA 1740
AKAPYLAKFK VKRCGVSELE KEGLQCRSDA EDECFSQEAD GKKICWQAAI FKVGDDCRQD 1800
MLALQIIDLF KNIFQLVGLD LFVFPYRVVA TAPGCGVIEC IPDCTSRDQL GRQTDFGMYD 1860
YFTRQYGDES TLAFQQARYN FIRSMAAYSL LLFLLQIKDR HNGNIMLDKK GHIIHIDFGF 1920
MFESSPGGNL GWEPDIKLTD EMVMIMGGKM EATPFKWFME MCVRGYLAVR PYMDAVVSLV 1980
TLMLDTGLPC FRGQTIKLLK HRFSPNMTER EAANFIMKVI QNCFLSNRSR TYDMIQYYQN 2040
DIPY 2044 
Gene Ontology
 GO:0005886; C:plasma membrane; IBA:RefGenome.
 GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IBA:RefGenome.
 GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR015433; PI_Kinase.
 IPR001263; PInositide-3_kin_accessory_dom. 
Pfam
 PF00454; PI3_PI4_kinase
 PF00613; PI3Ka 
SMART
 SM00145; PI3Ka
 SM00146; PI3Kc 
PROSITE
 PS00915; PI3_4_KINASE_1
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3
 PS51545; PIK_HELICAL 
PRINTS