UniProt Accession

 NDUAD_MOUSE; Q9ERS2; Q9DC98; Q9DCA1 

Genbank Protein ID

 AF286698; AK012422; AK010517; AK002999; AK003012; BC034899; BC037149; BC055435 

Genbank Nucleotide ID

 AAG28168.1; BAB28227.1; BAB26999.1; BAB22505.1; AAH34899.1; AAH37149.1; AAH55435.1 

Protein Name

 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 

Protein Synonyms/Alias

 Cell death regulatory protein GRIM-19; Complex I-B16.6; CI-B16.6; Gene associated with retinoic and interferon-induced mortality 19 protein; GRIM-19; Gene associated with retinoic and IFN-induced mortality 19 protein; NADH-ubiquinone oxidoreductase B16.6 subunit 

Gene Name

 Ndufa13 

Gene Synonyms/Alias

 Grim19 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
7	*MAASKVKQDMPPPG	acetylation	[1, 2]
22	GYGPIDYKRNLPRRG	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) cell death pathway. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Apoptosis; Complete proteome; Direct protein sequencing; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleus; Reference proteome; Respiratory chain; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 144 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005746; C:mitochondrial respiratory chain; ISS:UniProtKB.
 GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Compara.
 GO:0005654; C:nucleoplasm; ISS:UniProtKB.
 GO:0005524; F:ATP binding; TAS:MGI.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
 GO:0030262; P:apoptotic nuclear changes; ISS:UniProtKB.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0097191; P:extrinsic apoptotic signaling pathway; IDA:MGI.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0017148; P:negative regulation of translation; IEA:Compara.
 GO:0072593; P:reactive oxygen species metabolic process; IEA:Compara. 

Interpro

 IPR009346; GRIM-19. 

Pfam

 PF06212; GRIM-19 

SMART

  

PROSITE

  

PRINTS