CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028760
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 12 member 1 
Protein Synonyms/Alias
 Solute carrier family 12, member 1, isoform CRA_b 
Gene Name
 Slc12a1 
Gene Synonyms/Alias
 mCG_6138 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
102QTMDAVPKIEYYRNTubiquitination[1]
116TGSVSGPKVNRPSLLubiquitination[1]
131EIHEQLAKNVTVAPGubiquitination[1]
515KVFQALCKDNIFKGLubiquitination[1]
520LCKDNIFKGLQFFAKubiquitination[1]
717GPRKLCVKEMNSGMAubiquitination[1]
732KKQAWLIKNKIKAFYubiquitination[1]
824QVQDELEKLEQERLAubiquitination[1]
837LALEAAIKDNECEEGubiquitination[1]
845DNECEEGKGGIRGLFubiquitination[1]
862AGKLNITKPAPKKDGubiquitination[1]
866NITKPAPKKDGNISSubiquitination[1]
867ITKPAPKKDGNISSIubiquitination[1]
885HVGEFNQKLVEASAQubiquitination[1]
894VEASAQFKKKQGKGTubiquitination[1]
939LRIYVGGKINRIEEEubiquitination[1]
947INRIEEEKISMASLLubiquitination[1]
956SMASLLSKFRIKFADacetylation[2]
956SMASLLSKFRIKFADubiquitination[1]
973IIGDINIKPNKESWKubiquitination[1]
996YRLHESHKDLTTAEKubiquitination[1]
1003KDLTTAEKLKRESPWubiquitination[1]
1021DAELEAVKEKSYRQVubiquitination[1]
1023ELEAVKEKSYRQVRLubiquitination[1]
1083LLVRGNHKNVLTFYSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1090 AA 
Protein Sequence
MSVSIPSNSV PSSASRFQVH VINEGHGSAA AVGDSADPPH YEETSFGDEA QNRLRISFRP 60
GNQECYDNFL QTGETAKTDT TFHAYDSHTN TYYLQTMDAV PKIEYYRNTG SVSGPKVNRP 120
SLLEIHEQLA KNVTVAPGSA DRVANGDGMP GDEQAENKEE DMTGVVKFGW VKGVLVRCML 180
NIWGVMLFIR LSWIVGEAGI GLGVLIILLS TMVTSITGLS TSAIATNGFV RGGGAYYLIS 240
RSLGPEFGGS IGLIFAFANA VAVAMYVVGF AETVVDLLKE SDSMMVDPTN DIRIIGSITV 300
VILLGISVAG MEWEAKAQVI LLVILLIAIA NFFIGTVIPS NNEKKSRGFF NYQASIFAEN 360
FGPSFTKGEG FFSVFAIFFP AATGILAGAN ISGDLEDPQD AIPRGTMLAI FITTVAYIGV 420
AICVAACVVR DATGSMNDTI VSGMNCNGSA ACGLGYDFSR CQHEPCQYGL MNNFQVMSMV 480
SGFGPLITAG IFSATLSSAL ASLVSAPKVF QALCKDNIFK GLQFFAKGYG KNNEPLRGYF 540
LTFVIAMAFI LIAELNVIAP IISNFFLASY ALINFSCFHA SYAKSPGWRP AYGIYNMWVS 600
LFGAILCCAV MFVINWWAAV ITYVIELFLY IYVTYKKPDV NWGSSTQALS YVSALDNALE 660
LTTVEDHVKN FRPQCIVLTG GPMTRPALLD ITHAFTKNSG LCICCEVFVG PRKLCVKEMN 720
SGMAKKQAWL IKNKIKAFYA AVAADCFRDG VRSLLQASGL GRMKPNTLVI GYKKNWRKAP 780
LSELENYVGI IHDAFDFEIG VVIVRISQGF DISPVLQVQD ELEKLEQERL ALEAAIKDNE 840
CEEGKGGIRG LFKKAGKLNI TKPAPKKDGN ISSIQSMHVG EFNQKLVEAS AQFKKKQGKG 900
TIDVWWLFDD GGLTLLIPYI LTLRKKWKDC KLRIYVGGKI NRIEEEKISM ASLLSKFRIK 960
FADIHIIGDI NIKPNKESWK VFEEMIEPYR LHESHKDLTT AEKLKRESPW KITDAELEAV 1020
KEKSYRQVRL NELLQEHSRA ANLIVLSLPV ARKGSISDLL YMAWLEILTK NLPPVLLVRG 1080
NHKNVLTFYS 1090 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0015377; F:cation:chloride symporter activity; IEA:InterPro.
 GO:0048878; P:chemical homeostasis; IMP:MGI.
 GO:0007588; P:excretion; IMP:MGI.
 GO:0001822; P:kidney development; IMP:MGI. 
Interpro
 IPR004841; AA-permease_dom.
 IPR013612; AA_permease_N.
 IPR002443; Na/K/Cl_cotranspt.
 IPR002445; Na/K/Cl_cotranspt2.
 IPR004842; Na/K/Cl_cotransptS. 
Pfam
 PF00324; AA_permease
 PF08403; AA_permease_N 
SMART
  
PROSITE
  
PRINTS
 PR01207; NAKCLTRNSPRT.
 PR01209; NAKCLTRSPRT2.