UniProt Accession

 HMGN3_MOUSE; Q9DCB1; Q7M737; Q99JU1 

Genbank Protein ID

 AK002970; AK153223; BC005693; BK000004; BK000005 

Genbank Nucleotide ID

 BAB22485.1; BAE31816.1; AAH05693.1; DAA00393.1; DAA00394.1 

Protein Name

 High mobility group nucleosome-binding domain-containing protein 3 

Protein Synonyms/Alias

  

Gene Name

 Hmgn3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
13	SPENTEGKDGTKLTK	acetylation	[1]

Reference

 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 

Functional Description

 Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. 

Sequence Annotation

 MOD_RES 6 6 Phosphoserine.
 MOD_RES 10 10 Phosphothreonine (By similarity).
 MOD_RES 78 78 Phosphoserine (By similarity).
 MOD_RES 93 93 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Chromatin regulator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 99 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; IEA:InterPro.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0031492; F:nucleosomal DNA binding; IEA:InterPro.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus; IMP:MGI. 

Interpro

 IPR000079; HMGN_fam. 

Pfam

 PF01101; HMG14_17 

SMART

 SM00527; HMG17 

PROSITE

 PS00355; HMG14_17 

PRINTS

 PR00925; NONHISHMG17.