CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038239
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rho GTPase-activating protein 5 
Protein Synonyms/Alias
  
Gene Name
 Arhgap5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
278TATDKFEKLVQTVRDubiquitination[1]
333LKQEHIRKRREEYISubiquitination[1]
1060KLDPNLLKTIEAGIGubiquitination[1]
1100EPLDTIFKQKGYSDEubiquitination[1]
1102LDTIFKQKGYSDEIYubiquitination[1]
1209LSPVETWKGGIDNPAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1503 AA 
Protein Sequence
MMAKNKEPRP PSYTVSVVGL SGTEKDKGNC GVGKSCLCNR FVRSKADEYY PEHTSVLSTI 60
DFGGRVVNND HFLYWGDITQ NGEDGVECKI HVIEQTEFID DQTFLPHRST NLQPYIKRAA 120
ASKLQSAEKL MYICTDQLGL EQDFEQKQMP EGKLNVDGFL LCIDVSQGCN RKFDDQLKFV 180
NNLFVQLSKS KKPVIIAATK CDECVDHYLR EVQAFASNKK NLLVVETSAR FNVNIETCFT 240
ALVQMLDKTR GKPKIIPYLD AYKTQRQLVV TATDKFEKLV QTVRDYHATW KTVSNKLKNH 300
PDYEEYINLE GTRKARNTFS KHIEQLKQEH IRKRREEYIS TLPRAFNTLL PDLEEIEHLN 360
WLEALKLMEK RADFQLCFVV LEKTPWDETD HIDKINDRRI PFDLLSTLEA EKVYQNHVQH 420
LISEKRRIEM KEKFKKTLEK IQFISPGQPW EEVMCFVMED EAFKYITEAD SKEVYGRHQR 480
EIVEKAKEEF QEMLFEHSEL FYDLDLNATP SSDKMSEIHT VLSEEPRYKA LQKLAPDRES 540
LLLKHIGFVY HPTKETCLSG QYCTDIKVEN LLATSLLEMD HNRVRLYHDS TNIDKVNLFI 600
LGKDGLAQEL ANEIRTQSTD DEYALDGKIY ELDLRPVDAK SPYILSQLWT AAFKPHGCFC 660
VFNSIESLSF IGEFIGKIRT EASQIRKDKY MTNLPFTLIL ANQRDSISKN LPILRHQGQQ 720
LANKLQCPFV DVPTGTYPRK FNESQIKQAL RGVLESVKHN LDVVSPVPIN KDVSEADLRI 780
VMCAMCGDPF SVDLILSPFL DSHSCSAAQA GQNNSLMLDK IIGEKRRRIQ ITILSYHSSI 840
GVRKDELVHG YILVYSAKRK ASMGMLRAFL SEVQDTIPVQ LVAVTDSQAD FFENEAIKEL 900
MTEGEHIATE ITAKFTALYS LSQYHRQTEV FTLFFSDVLE KKNMIENSYL SDNTRESTHQ 960
SEDVFLPSPR DCFPYNNYPD SDDDTEAPPP YSPIGDDVQL LPTPSDRSRY RLDLEGNEYP 1020
VHSTPNCHDH ERNHKVPPPI KPKPVVPKTN VKKLDPNLLK TIEAGIGKNP RKQTSRVPLA 1080
HPEDMDSSDN YVEPLDTIFK QKGYSDEIYV VPDDSQNRII KIRNSFVNNT QGDEENGFSD 1140
RTSKGHGERR PSKYKYKSKT LFSKAKSYYR RTHSDASDDE AFTTSKTKRK GRHRGSEEDP 1200
LLSPVETWKG GIDNPAITSD QEVDDKKIKK KTHKVKEDKK QKKKTKTFNP PTRRNWESNY 1260
FGMPLQDLVT AEKPIPLFVE KCVEFIEDTG LCTEGLYRVS GNKTDQDNIQ KQFDQDHNIN 1320
LASMEVTVNA VAGALKAFFA DLPDPLIPYS LHPELLEAAK IPDKTERFHA LKEIVKKFHP 1380
VNYDVFRYVI THLNRVSQQN KINLMTADNL SICFWPTLMR PDFENREFLS TTKIHQSVVE 1440
TFIQQCQFFF YNGEIVETAN TVAPPPTSNP GQLVESMVPL QLPPPLQPQL IQPQLQTDPL 1500
GII 1503 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:InterPro.
 GO:0030335; P:positive regulation of cell migration; IMP:MGI.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:MGI.
 GO:0008361; P:regulation of cell size; IMP:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR002713; FF_domain.
 IPR027417; P-loop_NTPase.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom.
 IPR001806; Small_GTPase. 
Pfam
 PF01846; FF
 PF00071; Ras
 PF00620; RhoGAP 
SMART
 SM00441; FF
 SM00324; RhoGAP 
PROSITE
 PS50238; RHOGAP 
PRINTS
 PR00449; RASTRNSFRMNG.