CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008792
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pro-apoptotic serine protease NMA111 
Protein Synonyms/Alias
 111 kDa nuclear mediator of apoptosis 
Gene Name
 NMA111 
Gene Synonyms/Alias
 YNM3; YNL123W; N1897 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
15IKKRDHSKISDGTSGacetylation[1]
28SGESSLVKRKQLESAubiquitination[2]
194VGNDAGEKLSILAGFubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Nuclear serine protease which mediates apoptosis through proteolysis of the apoptotic inhibitor BIR1. 
Sequence Annotation
 DOMAIN 300 378 PDZ 1.
 DOMAIN 779 854 PDZ 2.
 REGION 83 273 Serine protease.
 ACT_SITE 121 121 Charge relay system (Potential).
 ACT_SITE 152 152 Charge relay system (Potential).
 ACT_SITE 235 235 Charge relay system (Potential).  
Keyword
 Apoptosis; Complete proteome; Hydrolase; Nucleus; Protease; Reference proteome; Repeat; Serine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 997 AA 
Protein Sequence
MTISLSNIKK RDHSKISDGT SGESSLVKRK QLESATGDQE EEYTDHEIII EPLHFANNNN 60
TVLTDSENYL RWQNTISNVV KSVVSIHFSQ VAPFDCDSAL VSEATGFVVD AKLGIILTNR 120
HVVGPGPFVG YVVFDNHEEC DVIPIYRDPV HDFGFLKFDP KNIKYSKIKA LTLKPSLAKV 180
GSEIRVVGND AGEKLSILAG FISRIDRNAP EYGELTYNDF NTEYIQAAAS ASGGSSGSPV 240
VNIDGYAVAL QAGGSTEAST DFFLPLDRIL RALICIQTNK PITRGTIQVQ WLLKPYDECR 300
RLGLTSERES EARAKFPENI GLLVAETVLR EGPGYDKIKE GDTLISINGE TISSFMQVDK 360
IQDENVGKEI QLVIQRGGVE CTVTCTVGDL HAITPHRYVE VCGATFHELS YQMARFYALP 420
VRGVFLSSAS GSFNFDSKER VGWIVDSIDN KETPDLDTFI EIMKTIPDRK RVTVRYHHLT 480
DQHSPLVTSI YIDRHWCNEF RVYTRNDTTG IWDYKNVADP LPADALKPRS AKIIPIPVNN 540
EKVAKLSSSL CTVATMAAVP LDSLSADILK TSGLIIDAEK GYVLVSRRVV PHDCLDTFVT 600
IADSLVVPAT VEFLHPTHNF AIVKYDPELV KAPLITPKLS TTRMKRGDKL QFIGFTQNDR 660
IVTSETTVTD ISSVSIPSNL IPRYRATNLE AISIDCNVST RCNSGILTDN DGTVRGLWLP 720
FLGERLENKE KVYLMGLDIM DCREVIDILK NGGKPRVSIV DAGFGSISVL QARIRGVPEE 780
WIMRMEHESN NRLQFITVSR VSYTEDKIHL ETGDVILSVN GKLVTEMNDL NGVVSSADGI 840
LPSAMLDFKV VRDGNIVDLK IKTVEVQETD RFVIFAGSIL QKPHHAVLQA MVDVPKGVYC 900
TFRGESSPAL QYGISATNFI THVNEIETPD LDTFLKVVKT IPDNSYCKMR LMTFDNVPFA 960
ISLKTNYHYF PTAELKRDNI THKWIEKEFT GNSQSEK 997 
Gene Ontology
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0008236; F:serine-type peptidase activity; IDA:SGD.
 GO:0006915; P:apoptotic process; IMP:SGD.
 GO:0044255; P:cellular lipid metabolic process; IMP:SGD.
 GO:0034605; P:cellular response to heat; IMP:SGD.
 GO:0030163; P:protein catabolic process; IMP:SGD.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001478; PDZ.
 IPR025926; PDZ-like_dom.
 IPR001940; Peptidase_S1C.
 IPR009003; Trypsin-like_Pept_dom. 
Pfam
 PF00595; PDZ
 PF12812; PDZ_1 
SMART
 SM00228; PDZ 
PROSITE
 PS50106; PDZ 
PRINTS
 PR00834; PROTEASES2C.