CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018404
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sensor protein QseC 
Protein Synonyms/Alias
  
Gene Name
 qseC 
Gene Synonyms/Alias
 STM3178 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
274DDPLSRDKALTQLHAacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation (By similarity). 
Sequence Annotation
 DOMAIN 183 235 HAMP.
 DOMAIN 243 449 Histidine kinase.
 MOD_RES 246 246 Phosphohistidine; by autocatalysis (By  
Keyword
 ATP-binding; Cell inner membrane; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Two-component regulatory system. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 449 AA 
Protein Sequence
MKLTQRLSLR VRLTLIFLIL VSITWAISSF VAWRKTTDNV DELFDTQLML FARRLSTLDL 60
NEINAPQRMA HTPKKLKHGH IDDDALAFAI FSADGKMLLH DGDNGQDIPY RYRREGFDNG 120
YLKDDNDLWR FLWLNSADGK YRIVVGQEWD YREDMALAIV AAQLTPWLIA LPFMLLILLL 180
LLHRELRPLK KLAQALRFRS PESETPLDAK GVPSEVRPLV EALNQLFSRI HSMMVRERRF 240
TSDAAHELRS PLAALKVQTE VAQLSGDDPL SRDKALTQLH AGIDRATRLV DQLLTLSRLD 300
SLNNLQDVAE ISLEELLQSA VMDIYHPAQQ ANIDVRLQLN AHDVIRTGQP LLLSLLVRNL 360
LDNAIRYSPQ GSVVDVTLHA RSFTVRDNGP GVAPEILTHI GERFYRPPGQ SVTGSGLGLS 420
IVRRIATLHG MTVSFGNAAE GGFEAVVSW 449 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC. 
Interpro
 IPR003660; HAMP_linker_domain.
 IPR003594; HATPase_ATP-bd.
 IPR004358; Sig_transdc_His_kin-like_C.
 IPR003661; Sig_transdc_His_kin_sub1_dim/P.
 IPR005467; Sig_transdc_His_kinase_core.
 IPR009082; Sig_transdc_His_kinase_dimeric. 
Pfam
 PF00672; HAMP
 PF02518; HATPase_c
 PF00512; HisKA 
SMART
 SM00387; HATPase_c
 SM00388; HisKA 
PROSITE
 PS50885; HAMP
 PS50109; HIS_KIN 
PRINTS
 PR00344; BCTRLSENSOR.