UniProt Accession

 PDIA2_HUMAN; Q13087; A6ZJ64; B4DI27; Q2WGM4; Q4TT67; Q6B010; Q96KJ6; Q9BW95 

Genbank Protein ID

 AB127078; AE006463; Z69667; Z69667; CH471112; BC000537; BC075029; U19948; AK295383 

Genbank Nucleotide ID

 BAE48734.1; AAK61223.1; CAI95586.1; CAO78188.1; EAW85838.1; AAH00537.2; AAH75029.1; AAC50401.1; BAG58339.1 

Protein Name

 Protein disulfide-isomerase A2 

Protein Synonyms/Alias

 Pancreas-specific protein disulfide isomerase; PDIp 

Gene Name

 PDIA2 

Gene Synonyms/Alias

 PDIP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
479	GRKVIEYKSTRDLET	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins. 

Sequence Annotation

 DOMAIN 27 152 Thioredoxin 1.
 DOMAIN 367 496 Thioredoxin 2.
 MOTIF 522 525 Prevents secretion from ER (Potential).
 ACT_SITE 71 71 Nucleophile (By similarity).
 ACT_SITE 74 74 Nucleophile (By similarity).
 ACT_SITE 418 418 Nucleophile (By similarity).
 ACT_SITE 421 421 Nucleophile (By similarity).
 CARBOHYD 127 127 N-linked (GlcNAc...).
 CARBOHYD 284 284 N-linked (GlcNAc...).
 CARBOHYD 516 516 N-linked (GlcNAc...).
 DISULFID 18 18 Interchain.
 DISULFID 71 74 Redox-active (By similarity).
 DISULFID 418 421 Redox-active (By similarity).  

Keyword

 Alternative splicing; Chaperone; Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Isomerase; Lipid-binding; Polymorphism; Redox-active center; Reference proteome; Repeat; Signal; Steroid-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 525 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0003756; F:protein disulfide isomerase activity; TAS:ProtInc.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0071456; P:cellular response to hypoxia; IMP:BHF-UCL.
 GO:0097194; P:execution phase of apoptosis; IMP:BHF-UCL.
 GO:0006662; P:glycerol ether metabolic process; IEA:InterPro.
 GO:0006621; P:protein retention in ER lumen; TAS:ProtInc.
 GO:0034976; P:response to endoplasmic reticulum stress; IMP:BHF-UCL. 

Interpro

 IPR005792; Prot_disulphide_isomerase.
 IPR005746; Thioredoxin.
 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS00014; ER_TARGET
 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS

 PR00421; THIOREDOXIN.